High and Low Contrast Visual Acuity Are Not Affected in Amyotrophic Lateral Sclerosis.
High and Low Contrast Visual Acuity Are Not Affected in Amyotrophic Lateral Sclerosis.
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DOI：
10.1371/journal.pone.0168714
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Jiang QL
中科院分区：
文献类型：
--
作者：
Moss HE;Samelson M;Mohan G;Jiang QL
根据对肌萎缩侧索硬化症(ALS)患者视功能损害和视网膜包裹体的组织病理学观察，ALS患者的传入视觉系统可能受到神经变性的影响。为了验证ALS患者视力受损的假设，我们比较了在多学科ALS诊所就诊的ALS患者(n=25)和年龄匹配的对照组(n=25)的三项视力指标。采用高对比度(白底黑字)和低对比度(白底2.5%，灰字1.25%)视力表，在屈光后受控光照条件下检测双眼和双眼视力。双眼视力总和计算为双眼视力与最佳单眼视力的差值。双眼或单眼高对比度视力或低对比度视力与肌萎缩侧索硬化症的诊断(广义估计方程模型考虑年龄)之间没有关联。肌萎缩侧索硬化症和对照组的双眼总和相似。ALS症状持续时间延长与1.25%低对比度视力下降之间存在少量关联。这项研究不证实先前关于肌萎缩侧索硬化症患者视力受损的观察结果，也不支持将这种特殊的视觉功能测量用于ALS患者视觉通路受累的大范围评估。
The afferent visual system may be affected by neuro-degeneration in amyotrophic lateral sclerosis (ALS) based on observations of visual function impairment and retinal inclusions on histopathology in ALS patients. To test the hypothesis that visual acuity is impaired in ALS, we compared three measures of visual acuity in ALS patients (n = 25) attending a multidisciplinary ALS clinic and age matched control subjects (n = 25). Bilateral monocular and binocular visual acuities were assessed using high contrast (black letters on white background) and low contrast (2.5%, 1.25% grey letters on white background) visual acuity charts under controlled lighting conditions following refraction. Binocular summation was calculated as the difference between binocular and best monocular acuity scores. There were no associations between binocular or monocular high contrast visual acuity or low contrast visual acuity and amyotrophic lateral sclerosis diagnosis (generalized estimating equation models accounting for age). Binocular summation was similar in both amyotrophic lateral sclerosis and control subjects. There was a small magnitude association between increased duration of ALS symptoms and reduced 1.25% low contrast visual acuity. This study does not confirm prior observations of impaired visual acuity in patients with amyotrophic lateral sclerosis and does not support this particular measure of visual function for use in broad scale assessment of visual pathway involvement in ALS patients.
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影响因子：
4.4
作者：
Cedarbaum, JM;Stambler, N;Nakanishi, A
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