Molecular neuroanatomy of the mouse medial preoptic area with reference to parental behavior

Molecular neuroanatomy of the mouse medial preoptic area with reference to parental behavior
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参考父母行为的小鼠内侧视前区的分子神经解剖学

DOI:
10.1007/s12565-018-0468-4
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发表时间:
2018
影响因子:
1.2
通讯作者:
Tsuneoka Yousuke
Tsuneoka Yousuke
中科院分区:
医学4区
文献类型:
--
作者:
Kazama M;Kato Y;Kakita A;Noguchi N;Urano Y;Masui K;Niida-Kawaguchi M;Yamamoto T;Watabe K;Kitagawa K;Shibata N.;Tsuneoka Yousuke

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视前内侧区(medial preoptic area,MPOA)位于下丘脑的前部,是调节父母行为、交配行为和攻击行为等本能行为的重要区域。与其在生殖行为中的作用相一致,MPOA大量表达性腺类固醇激素受体,并在其形态上显示出明显的性二型性。尽管MPOA的功能的重要性,小鼠MPOA亚区的解剖分界一直是混乱的,仍然不明确,因为它们的异质性和复杂性。在这篇综述中,我首先介绍了我们的组织学检查显示不同的MPOA亚区之间的分子表达的差异。我还提供了有用的分子标记来描绘小鼠MPOA亚区显示两性异形。基于这种解剖学研究在亚区水平上,我还总结了目前的理解的作用,小鼠MPOA和相邻的床核的终纹在父母的动机:中央部分的MPOA是必不可少的父母的动机,这方面施加了抑制作用的神经活动在BNST菱形核导致抑制杀。
The medial preoptic area (MPOA), an anterior part of the hypothalamus, is one of the most important areas for the regulation of instinctively motivated behaviors, such as parental behavior, mating behavior and aggression. Consistent with its role in reproductive behaviors, the MPOA abundantly expresses gonadal steroid hormone receptors and shows distinct sexual dimorphism in its morphology. Despite the functional importance of the MPOA, the anatomical demarcations of the mouse MPOA subregions have been confusing and remained undefined because of their heterogeneity and complexity. In this review, I first introduce our histological examination showing differential expression of various molecules among the MPOA subregions. I also provide useful molecular markers to delineate the mouse MPOA subregions showing sexual dimorphism. Based on this anatomical study at the subregion level, I also summarize the current understanding of the role of the mouse MPOA and adjacent bed nucleus of the stria terminalis in parental motivation: the central part of the MPOA is essential for parental motivation, and this area exerts an inhibitory effect on the neural activity in the BNST rhomboid nucleus resulting in suppressed infanticide.
妊娠、分娩和哺乳期大鼠视前区、下丘脑和脑干两种即刻早期基因蛋白FosB和Fos的表达比较。
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