The Degree of Early Life Stress Predicts Decreased Medial Prefrontal Activations and the Shift from Internally to Externally Guided Decision Making: An Exploratory NIRS Study during Resting State and Self-Oriented Task.
The Degree of Early Life Stress Predicts Decreased Medial Prefrontal Activations and the Shift from Internally to Externally Guided Decision Making: An Exploratory NIRS Study during Resting State and Self-Oriented Task.
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DOI：
10.3389/fnhum.2013.00339
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发表时间：
2013
影响因子：
2.9
通讯作者：
Yamawaki S
中科院分区：
文献类型：
--
作者：
Nakao T;Matsumoto T;Morita M;Shimizu D;Yoshimura S;Northoff G;Morinobu S;Okamoto Y;Yamawaki S
早期生活应激(ELS)是精神障碍的一个重要的精神病理学危险因素，在静息状态下与默认模式网络(DMN)内的功能连接性降低有关。此外，在工作记忆任务中，它与DMN中更大程度的去激活有关。尽管DMN在自我导向的任务中表现出很大幅度的极低频率振荡(Vlfo)和强烈的参与性，但这些特征与ELS的关系尚不清楚。因此，我们的初步研究利用近红外光谱(NIRS)研究了在静息状态和自我定向任务中ELS与额叶激活程度的关系。以22名健康受试者为受试者，分别在5 分钟静息状态、自我定向任务(颜色偏好判断)和对照任务(颜色相似性判断)下，记录43条前颞叶通道的局部血流动力学变化。使用儿童虐待和创伤量表，对ELS进行量化。我们观察到ELS与内侧前额叶皮质(MPFC)在静息状态和颜色偏好判断中的激活均呈负相关。相反，在颜色相似性判断中，ELS和MPFC激活之间没有发现显著的相关性。此外，我们观察到在颜色偏好判断中ELS和MPFC激活与偏好判断中的相似颜色选择率在行为上相关，这表明，对于ELS较高的参与者，颜色偏好判断中的决定是基于外部标准(颜色相似性)而不是内部标准(主观偏好)。综上所述，我们的神经和行为研究结果表明，在休息和自我导向任务中，高ELS与低MPFC激活有关。这在行为上表现为从内部指导决策向外部指导决策的异常转变，即使在需要内部指导的情况下也是如此。
Early life stress (ELS), an important risk factor for psychopathology in mental disorders, is associated neuronally with decreased functional connectivity within the default mode network (DMN) in the resting state. Moreover, it is linked with greater deactivation in DMN during a working memory task. Although DMN shows large amplitudes of very low-frequency oscillations (VLFO) and strong involvement during self-oriented tasks, these features’ relation to ELS remains unclear. Therefore, our preliminary study investigated the relationship between ELS and the degree of frontal activations during a resting state and self-oriented task using near-infrared spectroscopy (NIRS). From 22 healthy participants, regional hemodynamic changes in 43 front-temporal channels were recorded during 5 min resting states, and execution of a self-oriented task (color-preference judgment) and a control task (color-similarity judgment). Using a child abuse and trauma scale, ELS was quantified. We observed that ELS showed a negative correlation with medial prefrontal cortex (MPFC) activation during both resting state and color-preference judgment. In contrast, no significant correlation was found between ELS and MPFC activation during color-similarity judgment. Additionally, we observed that ELS and the MPFC activation during color-preference judgment were associated behaviorally with the rate of similar color choice in preference judgment, which suggests that, for participants with higher ELS, decisions in the color-preference judgment were based on an external criterion (color similarity) rather than an internal criterion (subjective preference). Taken together, our neuronal and behavioral findings show that high ELS is related to lower MPFC activation during both rest and self-oriented tasks. This is behaviorally manifest in an abnormal shift from internally to externally guided decision making, even under circumstances where internal guidance is required.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.2
作者：
Heim, Christine;Shugart, Margaret;Nemeroff, Charles B.
通讯作者：
Nemeroff, Charles B.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
6.9
作者：
Cisler, J. M.;James, G. A.;Kilts, C. D.
通讯作者：
Kilts, C. D.
DOI：
10.1196/annals.1440.011
发表时间：
2008-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2008
影响因子：
--
作者：
Buckner, Randy L.;Andrews-Hanna, Jessica R.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.