Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study.
Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study.
复制标题
DOI：
10.3389/fpubh.2021.710504
复制
发表时间：
2021
影响因子：
5.2
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Meng X;Zou H;Li D;Yu P;Huang L;Zhang J;Li W;Yu X
背景：慢性肾脏病（CKD）是公认的主要公共卫生问题，具有高发病率和死亡率。近年来发现血管生成素样蛋白8（angiopoietin-like protein 8，ANGPTL 8）具有调节脂质代谢的作用。既往研究提示，糖尿病患者血清ANGPTL 8水平升高，尤其是伴有白蛋白尿的糖尿病患者。本研究旨在研究一般人群中ANGPTL 8循环水平与肾功能之间的相关性。研究方法：受试者是来自中国糖尿病个体cAncers风险评估：一项长期研究（REACTION研究）的肾功能不全患者[估计肾小球滤过率（eGFR）<60/min/1.73 m2]。每例病例均按年龄、性别和体重指数（BMI）匹配，其中1例对照组eGFR ≥ 90 ml/min/1.73 m2。使用配对t检验比较病例组和对照组。采用二元Logistic回归分析计算肾功能不全（RD）的比值比（OR）。结果如下：在135个病例-对照对中，与对照受试者相比，RD患者的循环ANGPTL 8水平升高[799.96（410.12-1086.44）vs.609.58（365.13-740.06）pg/ml，p < 0.05]。偏相关显示ANGPTL 8水平与eGFR呈负相关（r =-0.26，p < 0.05）。多变量校正的二元logistic回归分析显示，ANGPTL 8水平升高与RD风险增加相关（OR为四分位数4 vs. 1，3.80; 95%CI，1.71-8.41）。有趣的是，ANGPTL 8水平与RD之间的相关性与亚组分析中非糖尿病个体（OR，1.44; 95%CI，1.09 - 1.91）和糖尿病患者（OR，2.71; 95%CI，1.13-6.49）的总体结果一致。此外，这种关联的估计值在女性中也很显著（OR，2.12; 95%CI，1.33-3.37），年龄> 60岁的个体（OR，1.55; 95% CI，1.16-2.07），BMI <24的个体（OR，1.66; 95%CI，1.16-2.39）和没有胆固醇血症的个体（OR，1.61; 95%CI，1.16-2.23）（所有p值<0.05）。结论：在一般人群中，升高的循环ANGPTL 8水平与RD风险增加相关，特别是在女性、年龄> 60岁的个体、BMI < 24的个体、无糖尿病的个体、糖尿病（DM）个体和无糖尿病的个体中。这一发现表明ANGPTL 8可能在RD的病理过程中发挥作用。
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with albuminuria. This study aimed to investigate the association between circulating levels of ANGPTL8 and kidney function in the general population. Methods: The subjects were patients with renal dysfunction [estimated glomerular filtration rate (eGFR) <60/min/1.73 m2] from Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study (the REACTION study). Each case was matched by age, sex, and body mass index (BMI) with one control whose eGFR was ≥ 90 ml/min/1.73 m2. The case and control groups were compared using a paired t-test. Binary logistic regression analysis was used to calculate the odds ratio (OR) of renal dysfunction (RD). Results: Among 135 case-control pairs, circulating ANGPTL8 levels were elevated in patients with RD compared to control subjects [799.96 (410.12-1086.44) vs. 609.58 (365.13-740.06) pg/ml, p < 0.05]. Partial correlations showed that ANGPTL8 levels were negatively correlated with eGFR (r = −0.26, p < 0.05). Multivariable-adjusted binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with an increased risk of RD (OR in quartile 4 vs. 1, 3.80; 95% CI, 1.71-8.41). Interestingly, the association between ANGPTL8 levels and RD was consistent with the overall findings in both nondiabetic individuals (OR, 1.44; 95% CI, 1.09 to 1.91) and diabetic patients (OR, 2.71; 95% CI, 1.13-6.49) in the subgroup analyses. Furthermore, the estimates for this association were also significant in females (OR, 2.12; 95% CI, 1.33-3.37), individuals aged > 60 years (OR, 1.55; 95% CI, 1.16-2.07), individuals with a BMI <24 (OR, 1.66; 95% CI, 1.16-2.39), and individuals without hyperlipidaemia (OR, 1.61; 95% CI, 1.16-2.23) (all p-values <0.05). Conclusion: Elevated circulating ANGPTL8 levels were associated with increased risk of RD in the general population, especially among females, individuals aged > 60 years, individuals with a BMI < 24, individuals without diabetes mellitus, individuals with diabetes mellitus (DM), and individuals without hyperlipidaemia. This finding implies that ANGPTL8 may play a role in the pathological process of RD.
登录
查看更多内容
影响因子：
9.3
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者：
Wang CH
CKD 中的 AKI：损伤加剧、修复受到抑制及其潜在机制
影响因子：
19.6
作者：
He L;Wei Q;Liu J;Yi M;Liu Y;Liu H;Sun L;Peng Y;Liu F;Venkatachalam MA;Dong Z
通讯作者：
Dong Z
影响因子：
6.5
作者：
Issa, Yasmine Amr;Abd ElHafeez, Samar Samy;Amin, Noha Gaber
通讯作者：
Amin, Noha Gaber
影响因子：
168.9
作者：
Jha, Vivekanand;Garcia-Garcia, Guillermo;Yang, Chih-Wei
通讯作者：
Yang, Chih-Wei
影响因子：
3.7
作者：
Maurer L;Schwarz F;Fischer-Rosinsky A;Schlueter N;Brachs S;Möhlig M;Pfeiffer A;Mai K;Spranger J;Bobbert T
通讯作者：
Bobbert T