Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.

Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.
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DOI:
10.1016/j.ydbio.2019.04.002
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发表时间:
2019-07-01
影响因子:
2.7
通讯作者:
Miller DM 3rd
Miller DM 3rd
中科院分区:
生物学3区
文献类型:
--
作者:
Sundararajan L;Stern J;Miller DM 3rd

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单个神经元的形状与其功能有关,轴突向其他细胞发送信号,树突接收信号。虽然我们对轴突生长的机制了解很多,但树突结构的惊人复杂性阻碍了我们揭示树突分支途径的努力。在这里,我们回顾的结果,实验策略,利用遗传分析和活细胞成像的PVD感觉神经元在C。揭示树突形态发生的关键分子驱动因素。
The shape of an individual neuron is linked to its function with axons sending signals to other cells and dendrites receiving them. Although much is known of the mechanisms for axonal outgrowth, the striking complexity of dendritic architecture has hindered efforts to uncover pathways that direct dendritic branching. Here we review the results of an experimental strategy that exploits the power of genetic analysis and live cell imaging of the PVD sensory neuron in C. elegans to reveal key molecular drivers of dendrite morphogenesis.
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