UTE-T2∗ mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear.
UTE-T2∗ mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear.
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DOI：
10.1016/j.joca.2012.01.009
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发表时间：
2012-06
影响因子：
7
通讯作者：
Chu CR
中科院分区：
文献类型：
--
作者：
Williams A;Qian Y;Golla S;Chu CR
半月板撕裂是骨关节炎(OA)的已知危险因素。在半月板表面破裂之前，对半月板退变进行定量评估，对于识别潜在的治疗干预措施的早期疾病很重要。这项工作检验了超短回声时间增强T2*(UTE-T2*)图在体内和体外检测人类半月板退行性变的诊断潜力。将16具身体半月板的UTE-T2*图与半月板结构完整性的组织学评估和肌肉骨骼放射科医生的临床磁共振成像(MRI)评估进行了比较。对10例无症状受试者和25例伴有和不伴有半月板撕裂的前交叉韧带损伤患者的UTE-T2*MAP进行了体内比较。在体外，UTE-T2*值在组织学和临床上正常的半月板组织中倾向于较低，而在撕裂或退变组织中倾向于较高。UTE-T2*MAP异质性反映胶原结构紊乱。在体内，无症状半月板UTE-T2*值的重复性在9%以内(均方根平均变异系数)。临床诊断为内侧半月板撕裂的前交叉韧带损伤患者(n=10)的后内侧半月板UTE-T2*值比无症状患者(n=10，P<；0.001)高87%。无内侧半月板撕裂的前交叉韧带损伤患者(n=15)的后内侧半月板UTE-T2*值比无症状患者高33%(P=0.001)。后外侧半月板UTE-T2*值也随关节病理程度的不同而有显著差异(P=0.001)。无临床证据的前交叉韧带损伤受试者半月板UTE-T2*值显著升高，提示UTE-T2*标测对亚临床半月板退行性变敏感。还需要进一步的研究来确定表面下半月板UTE-T2*值升高是否预示半月板退变的进展和骨关节炎的发展。
Meniscus tear is a known risk factor for osteoarthritis (OA). Quantitative assessment of meniscus degeneration, prior to surface break-down, is important to identification of early disease potentially amenable to therapeutic interventions. This work examines the diagnostic potential of ultrashort echo time-enhanced T2* (UTE-T2*) mapping to detect human meniscus degeneration in vitro and in vivo in subjects at risk of developing OA. UTE-T2* maps of 16 human cadaver menisci were compared to histological evaluations of meniscal structural integrity and clinical magnetic resonance imaging (MRI) assessment by a musculoskeletal radiologist. In vivo UTE-T2* maps were compared in 10 asymptomatic subjects and 25 ACL-injured patients with and without concomitant meniscal tear. In vitro, UTE-T2* values tended to be lower in histologically and clinically normal meniscus tissue and higher in torn or degenerate tissue. UTE-T2* map heterogeneity reflected collagen disorganization. In vivo, asymptomatic meniscus UTE-T2* values were repeatable within 9% (root-mean-square average coefficient of variation). Posteromedial meniscus UTE-T2* values in ACL-injured subjects with clinically diagnosed medial meniscus tear (n = 10) were 87% higher than asymptomatics (n = 10, P < 0.001). Posteromedial menisci UTE-T2* values of ACL-injured subjects without concomitant medial meniscal tear (n = 15) were 33% higher than asymptomatics (P = 0.001). Posterolateral menisci UTE-T2* values also varied significantly with degree of joint pathology (P = 0.001). Significant elevations of UTE-T2* values in the menisci of ACL-injured subjects without clinical evidence of subsurface meniscal abnormality suggest that UTE-T2* mapping is sensitive to subclinical meniscus degeneration. Further study is needed to determine whether elevated subsurface meniscus UTE-T2* values predict progression of meniscal degeneration and development of OA.
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影响因子：
4.9
作者：
Ding C;Martel-Pelletier J;Pelletier JP;Abram F;Raynauld JP;Cicuttini F;Jones G
通讯作者：
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