Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins.
Ongoing Assessment of the Molecular Evolution of Peste Des Petits Ruminants Virus Continues to Question Viral Origins.
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DOI：
10.3390/v13112144
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发表时间：
2021-10-25
期刊：
影响因子：
--
通讯作者：
Parida S
中科院分区：
文献类型：
--
作者：
Mahapatra M;Pachauri R;Subramaniam S;Banyard AC;ChandraSekar S;Ramakrishnan MA;Njeumi F;Muthuchelvan D;Parida S
了解病毒病原体的进化对于能够确定病毒如何在不同的环境中出现至关重要。宿主易感性在不同物种之间传播，是疾病随后流行病学的一个促成因素，由病毒检测和随后的表征来定义。小反刍兽疫病毒是一种小型反刍动物的瘟疫，对整个非洲和亚洲大部分地区的可持续农业发展造成相当大的负担。近年来，该病毒还对濒危物种种群产生了重大影响，突出表明它是地球仪不同区域高度关注的病原体。在这里，我们使用新的遗传数据重新评估了这种病毒的分子进化，试图进一步解决这种疾病的分子流行病学。病毒分离株的遗传特征分为四个谱系（I-IV），这些谱系的历史起源对病毒的分子进化具有相当大的意义。我们使用新的基因组序列对病毒出现的重新评估表明，谱系I、II和IV可能起源于西非的塞内加尔（I）和尼日利亚（II和IV）。谱系III序列预测出现在东非（埃塞俄比亚）或阿拉伯半岛（阿曼和/或阿拉伯联合酋长国），缺乏数据排除了更精确的解释。随着新数据的产生，对进化出现的不断改进是从历史角度理解病毒进化和了解这种病毒正在进行的基因出现的关键。
Understanding the evolution of viral pathogens is critical to being able to define how viruses emerge within different landscapes. Host susceptibility, which is spread between different species and is a contributing factor to the subsequent epidemiology of a disease, is defined by virus detection and subsequent characterization. Peste des petits ruminants virus is a plague of small ruminant species that is a considerable burden to the development of sustainable agriculture across Africa and much of Asia. The virus has also had a significant impact on populations of endangered species in recent years, highlighting its significance as a pathogen of high concern across different regions of the globe. Here, we have re-evaluated the molecular evolution of this virus using novel genetic data to try and further resolve the molecular epidemiology of this disease. Viral isolates are genetically characterized into four lineages (I−IV), and the historic origin of these lineages is of considerable interest to the molecular evolution of the virus. Our re-evaluation of viral emergence using novel genome sequences has demonstrated that lineages I, II and IV likely originated in West Africa, in Senegal (I) and Nigeria (II and IV). Lineage III sequences predicted emergence in either East Africa (Ethiopia) or in the Arabian Peninsula (Oman and/or the United Arab Emirates), with a paucity of data precluding a more refined interpretation. Continual refinements of evolutionary emergence, following the generation of new data, is key to both understanding viral evolution from a historic perspective and informing on the ongoing genetic emergence of this virus.
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影响因子：
4.3
作者：
Tounkara, Kadidia;Kwiatek, Olivier;Sidibe, Cheick Abou Kounta;Sery, Amadou;Dakouo, Marthin;Salami, Habib;Lo, Modou Moustapha;Ba, Aminata;Diop, Mariame;Niang, Mamadou;Libeau, Genevieve;Bataille, Arnaud
通讯作者：
Bataille, Arnaud
影响因子：
5.3
作者：
Benfield CTO;Hill S;Shatar M;Shiilegdamba E;Damdinjav B;Fine A;Willett B;Kock R;Bataille A
通讯作者：
Bataille A
影响因子：
3.7
作者：
Bao J;Wang Q;Li L;Liu C;Zhang Z;Li J;Wang S;Wu X;Wang Z
通讯作者：
Wang Z
影响因子：
2.7
作者：
Sahu, Amit Ranjan;Wani, Sajad Ahmad;Gandham, Ravi Kumar
通讯作者：
Gandham, Ravi Kumar
DOI：
10.3390/v13010059
发表时间：
2021-01-05
期刊：
Viruses
影响因子：
--
作者：
Zhao H;Njeumi F;Parida S;Benfield CTO
通讯作者：
Benfield CTO