Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation
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视黄酸诱导分化过程中人神经母细胞瘤细胞 c-myb 表达的调节

DOI:
10.1128/mcb.8.4.1677-1683.1988
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发表时间:
1988
影响因子:
5.3
通讯作者:
M. Israel
M. Israel
中科院分区:
生物学2区
文献类型:
--
作者:
C. Thiele;P. Cohen;M. Israel

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我们检测到c-myb原癌基因的表达,这最初被认为是以组织特异性的方式在造血谱系细胞中表达,在人类组织的神经元来源。由于c-myb的表达水平在胎儿发育过程中下降,我们研究了其在人神经母细胞瘤细胞系中的表达调控,视黄酸诱导分化。c-myb的表达在神经母细胞瘤细胞成熟过程中下降,这种变化是由c-myb转录的减少介导的。
We detected expression of the c-myb proto-oncogene, which was initially thought to be expressed in a tissue-specific manner in cells of hematopoietic lineage, in human tissues of neuronal origin. Since the level of c-myb expression declined during fetal development, we studied the regulation of its expression in human neuroblastoma cell lines induced to differentiate by retinoic acid. The expression of c-myb declined during the maturation of neuroblastoma cells, and this change was mediated by a decrease in c-myb transcription.
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