Cardiovascular disease and primary ovarian insufficiency.
Cardiovascular disease and primary ovarian insufficiency.
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DOI：
10.1055/s-0031-1280918
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发表时间：
2011-07
影响因子：
2.7
通讯作者：
Wellons M
中科院分区：
文献类型：
--
作者：
Wellons M
心血管疾病（CVD）是女性的头号杀手。原发性卵巢功能不全（POI）的女性可能比正常绝经的女性更容易患心血管疾病，如心肌梗死和中风。增加的负担可能是由心血管危险因素的恶化介导的，如脂质，与卵巢功能的丧失相对应。相反，增加的负担可能是由CVD事件和卵巢功能下降之前的因素引起的，例如X染色体异常和吸烟。无论原因如何，患有POI的女性可能是CVD筛查和预防策略的重要目标人群。这些策略应包括使用CVD风险分层工具，以确定可能受益于生活方式改变和药物治疗，以预防CVD的妇女。基于缺乏证据，不能推荐性类固醇治疗仅用于预防POI女性的CVD。
Cardiovascular disease (CVD) is the number-one killer of women. Women with primary ovarian insufficiency (POI) may be more burdened by cardiovascular disease, such as myocardial infarction and stroke, as compared with women with normal menopause. The increased burden may be mediated by a worsening of cardiovascular risk factors, such as lipids, corresponding with the loss of ovarian function. In contrast, the increased burden may be caused by factors that precede and potentially contribute to both CVD events and ovarian decline, such as X-chromosome abnormalities and smoking. Regardless of the cause, women with POI may serve as an important population to target for CVD screening and prevention strategies. These strategies should include the use of CVD risk stratification tools to identify women that may benefit from lifestyle modification and pharmacological therapy to prevent CVD. Sex steroid therapy for the sole purpose of CVD prevention in women with POI cannot be recommended, based on a lack of evidence.
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