Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility.
Estrogen catechols detection as biomarkers in schistosomiasis induced cancer and infertility.
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DOI：
10.2174/1570180813666160720165057
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发表时间：
2017
影响因子：
1
通讯作者：
Richter J
中科院分区：
文献类型：
--
作者：
Botelho MC;Alves H;Richter J
尿路血吸虫病是一种由人血吸虫血吸虫引起的慢性感染。血吸虫病血吸虫是一种已知的致癌危险因素，可导致膀胱鳞癌。这是一种在非洲和中东许多国家流行的被忽视的热带病。血吸虫卵产生儿茶酚雌激素。这些分子被代谢成活性的苯二酚，从而导致DNA的变化(在其他情况下会导致乳腺癌或甲状腺癌)。我们的研究小组已经证明，血吸虫卵相关的儿茶酚雌激素诱导尿路上皮细胞肿瘤样表型，起源于寄生虫雌激素-宿主细胞染色体DNA加合物和突变。在这里，我们回顾了最近关于雌激素-DNA加合物的作用以及它们如何在尿液中脱落可能是血吸虫感染的预后和/或作为泌尿生殖系统血吸虫病相关膀胱癌和不孕症的潜在生物标志物的研究结果。
Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active quinones that cause alterations in DNA (leading in other contexts to breast or thyroid cancer). Our group have shown that schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells, originated from parasite estrogen-host cell chromosomal DNA adducts and mutations. Here we review recent findings on the role of estrogen–DNA adducts and how their shedding in urine may be prognostic of schistosome infection and/or represent potential biomarkers for urogenital schistosomiasis associated bladder cancer and infertility.
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影响因子：
2.1
作者：
Botelho, M. C.;Crespo, M.;Correia da Costa, J. M.
通讯作者：
Correia da Costa, J. M.
影响因子：
2.1
作者：
Botelho, Monica Catarina;Soares, Raquel;Correia da Costa, Jose Manuel
通讯作者：
Correia da Costa, Jose Manuel
影响因子：
3.7
作者：
Santos J;Gouveia MJ;Vale N;Delgado Mde L;Gonçalves A;da Silva JM;Oliveira C;Xavier P;Gomes P;Santos LL;Lopes C;Barros A;Rinaldi G;Brindley PJ;da Costa JM;Sousa M;Botelho MC
通讯作者：
Botelho MC
影响因子：
4
作者：
Botelho, Monica C.;Vale, Nuno;Correia da Costa, Jose Manuel
通讯作者：
Correia da Costa, Jose Manuel
DOI：
10.1016/s0140-6736(13)61949-2
发表时间：
2014-06-28
期刊：
Lancet (London, England)
影响因子：
--
作者：
Colley DG;Bustinduy AL;Secor WE;King CH
通讯作者：
King CH