Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.
Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.
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DOI：
10.1186/1475-2840-12-177
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发表时间：
2013-12-27
影响因子：
9.3
通讯作者：
Araki E
中科院分区：
文献类型：
--
作者：
Matsumura T;Taketa K;Motoshima H;Senokuchi T;Ishii N;Kinoshita H;Fukuda K;Yamada S;Kukidome D;Kondo T;Hisada A;Katoh T;Shimoda S;Nishikawa T;Araki E
白细胞计数增加是心血管事件的独立危险因素，但白细胞亚型计数与糖尿病患者颈动脉粥样硬化之间的关联尚未确定。因此，我们研究了 2 型糖尿病受试者的白细胞亚型计数与颈总动脉内膜中层厚度 (CCA-IMT) 之间的相关性。这项横断面研究涉及 484 名 2 型糖尿病住院患者（282 名男性和 202 名女性），他们于 2005 年至 2011 年间因血糖控制而住院并在熊本大学医院接受了颈动脉超声检查。平均和最大 CCA-IMT 通过高分辨率 B 型超声检查进行测量。单变量分析显示，平均CCA-IMT与年龄、收缩压、臂踝脉搏波速度（PWV）、尿白蛋白排泄量和糖尿病病程呈正相关，但与舒张压和空腹血糖呈负相关。除空腹血糖外，最大 CCA-IMT 与平均 CCA-IMT 相同的因素呈正相关和负相关。平均 CCA-IMT 与白细胞总数 (r = 0.124，p = 0.007)、单核细胞 (r = 0.373，p < 0.001)、中性粒细胞 (r = 0.139，p = 0.002) 和嗜酸性粒细胞 (r = 0.107, p = 0.019) 计数。最大CCA-IMT与白细胞总数（r = 0.154，p < 0.001）、单核细胞（r = 0.398，p < 0.001）、中性粒细胞（r = 0.152，p < 0.001）和嗜碱性粒细胞呈正相关计数（r = 0.102，p = 0.027）。多元回归分析显示，单核细胞计数、年龄和 PWV 是与平均 CCA-IMT 相关的显着且独立的因素（调整后的 R2 = 0.239，p< 0.001），单核细胞计数、年龄和尿白蛋白排泄量是与最大 CCA-IMT 相关的显着且独立的因素（调整后的 R2 = 0.277， p < 0.001)。 2 型糖尿病患者的单核细胞计数与平均 CCA-IMT 和最大 CCA-IMT 呈正相关。单核细胞计数可能是 2 型糖尿病患者大血管并发症的有用预测因子。试用登记号：UMIN000003526。
An increased leukocyte count is an independent risk factor for cardiovascular events, but the association between leukocyte subtype counts and carotid atherosclerosis in patients with diabetes has not been determined. We therefore investigated the correlation between leukocyte subtype counts and intima-media thickness of the common carotid artery (CCA-IMT) in subjects with type 2 diabetes. This cross-sectional study involved 484 in-patients with type 2 diabetes (282 males and 202 females), who were hospitalized for glycemic control and underwent carotid ultrasonography at Kumamoto University Hospital between 2005 and 2011. Mean and maximum CCA-IMT was measured by high-resolution B-mode ultrasonography. Univariate analyses revealed that mean CCA-IMT was positively correlated with age, systolic blood pressure, brachial-ankle pulse wave velocity (PWV), urinary albumin excretion and duration of diabetes, but was negatively correlated with diastolic blood pressure and fasting plasma glucose. Maximum CCA-IMT was positively and negatively correlated with the same factors as mean CCA-IMT except for fasting plasma glucose. Mean CCA-IMT was positively correlated with total leukocyte (r = 0.124, p = 0.007), monocyte (r = 0.373, p < 0.001), neutrophil (r = 0.139, p = 0.002) and eosinophil (r = 0.107, p = 0.019) counts. Maximum CCA-IMT was positively correlated with total leukocyte (r = 0.154, p < 0.001), monocyte (r = 0.398, p < 0.001), neutrophil (r = 0.152, p < 0.001) and basophil counts (r = 0.102, p = 0.027). Multiple regression analyses showed that monocyte count, age and PWV were significant and independent factors associated with mean CCA-IMT (adjusted R2 = 0.239, p < 0.001), and that monocyte count, age and urinary albumin excretion were significant and independent factors associated with maximum CCA-IMT (adjusted R2 = 0.277, p < 0.001). Monocyte counts were positively correlated with both mean CCA-IMT and maximum CCA-IMT in patients with type 2 diabetes. Monocyte count may be a useful predictor of macrovascular complications in patients with type 2 diabetes. Trial registry no: UMIN000003526.
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影响因子：
11.1
作者：
GROBBEE, DE;BOTS, ML
通讯作者：
BOTS, ML
影响因子：
16.2
作者：
Aso, Y;Okumura, K;Inukai, T
通讯作者：
Inukai, T
影响因子：
3.3
作者：
Nozawa, Naoki;Hibi, Kiyoshi;Kimura, Kazuo
通讯作者：
Kimura, Kazuo
影响因子：
37.8
作者：
PIGNOLI, P;TREMOLI, E;PAOLETTI, R
通讯作者：
PAOLETTI, R
影响因子：
2.7
作者：
Phillips, A. C.;Jiang, C. Q.;Lam, T. H.
通讯作者：
Lam, T. H.