Research Review: Conflicts of Interest (COIs) in autism early intervention research - a meta-analysis of COI influences on intervention effects.
Research Review: Conflicts of Interest (COIs) in autism early intervention research - a meta-analysis of COI influences on intervention effects.
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DOI：
10.1111/jcpp.13249
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Woynaroski TG
中科院分区：
文献类型：
--
作者：
Bottema-Beutel K;Crowley S;Sandbank M;Woynaroski TG
利益冲突 (COI) 的存在、类型、披露率和对自闭症早期干预研究的影响此前尚未研究过。本研究的目的是研究这些问题。这项研究是对 1970 年至 2018 年间进行的所有分组设计、非药理学早期干预自闭症研究的综合荟萃分析的二次分析。我们对 COI 声明是否存在、披露的 COI 类型以及 8 种 COI 的报告进行了编码，包括：(a) 作者开发了干预措施，(b) 作者隶属于临床提供者，(c) 作者受雇于临床提供者，(d)作者隶属于培训他人使用干预措施的机构，(e) 作者收到与干预相关的付款或特许权使用费，(f) 该研究由干预提供者资助，(g) 该研究使用了作者开发的商业可用措施，以及 (h) 干预收益资助作者的研究。计算频率和比例以确定 COI 的普遍程度和 COI 披露。荟萃分析用于估计 COI 类型的汇总效应，并确定它们是否大于没有编码 COI 的报告。 70% 的报告针对 ≥ 1 个 COI 进行编码，但只有约 6% 的报告包含完全说明所有编码 COI 的 COI 语句。元回归没有检测到任何 COI 类型对汇总效果的显着影响，但是每种 COI 类型的点估计值大于没有编码 COI 的报告。在自闭症早期干预研究中，COI 很普遍，但报道不足。改进报告实践对于提高研究人员的透明度是必要的，并且可以更强有力地检查 COI 对研究结果的影响。
The presence, types, disclosure rates, and effects of conflicts of interest (COIs) on autism early intervention research have not previously been studied. The purpose of this study was to examine these issues. This study is a secondary analysis of a comprehensive meta-analysis of all group-design, non-pharmacological early intervention autism research conducted between 1970 and 2018. We coded reports for the presence/absence of COI statements, the types of COIs that were disclosed, and for 8 types of COIs, including: (a) the author developed the intervention, (b) the author is affiliated with a clinical provider, (c) the author is employed by a clinical provider, (d) the author is affiliated with an institution that trains others to use the intervention, (e) the author receives payment or royalties related to the intervention, (f) the study was funded by an intervention provider, (g) the study used a commercially available measure developed by the author, and (h) proceeds of the intervention fund the author’s research. Frequencies and proportions were calculated to determine prevalence of COIs and COI disclosures. Meta-analysis was used to estimate summary effects by COI type, and to determine if they were larger than for reports with no coded COIs. Seventy percent of reports were coded for ≥ 1 COI, but only ~6% of reports contained COI statements fully accounting for all coded COIs. Meta-regressions did not detect significant influences of any COI type on summary effects, however point estimates for each COI type were larger than for reports with no coded COIs. COIs are prevalent but under-reported in autism early intervention research. Improved reporting practices are necessary for researcher transparency, and would enable more robust examination of the effects of COIs on research outcomes.
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DOI：
10.1177/1745691612459058
发表时间：
2012-11
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
Nosek BA;Spies JR;Motyl M
通讯作者：
Motyl M
影响因子：
5.7
作者：
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通讯作者：
Liang, Mike K.
影响因子：
1.6
作者：
Gorman, Dennis M.;Conde, Eugenia
通讯作者：
Conde, Eugenia
影响因子：
19.9
作者：
Ioannidis, John P. A.;Munafo, Marcus R.;Fusar-Poli, Paolo;Nosek, Brian A.;David, Sean P.
通讯作者：
David, Sean P.
影响因子：
3.7
作者：
Eisner, Manuel;Humphreys, David K.;Gardner, Frances
通讯作者：
Gardner, Frances