Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions.
Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions.
复制标题
利培酮预处理可防止新生儿海马病变后运动活动升高。
DOI：
10.1038/sj.npp.1300791
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
McNamara,RobertK
中科院分区：
文献类型：
--
作者：
Richtand,NeilM;Taylor,Benjamin;Welge,JeffreyA;Ahlbrand,Rebecca;Ostrander,MichelleM;Burr,Jeffrey;Hayes,Scott;Coolen,LiqueM;Pritchard,LaurelM;Logue,Aaron;Herman,JamesP;McNamara,RobertK
在新生儿海马损伤后的大鼠中，青春期后出现长期行为异常，提供了异常大鼠行为的发育模型，其在鉴定有效治疗精神分裂症症状的化合物中可能具有预测有效性。我们试图测试的预测有效性的新生儿海马损伤模型在确定预防性治疗首发精神病。我们确定了利培酮的效果，最近研究的预防首发精神病，对发展的运动活动升高后，新生儿海马病变。大鼠幼崽在出生后第7天接受海马或假损伤，随后在出生后第35至56天接受利培酮或溶媒治疗。在出生后第57天，确定了对新奇、安非他明和夜间运动的运动活性。低剂量利培酮（45 μg/kg）预处理可防止新生儿海马损伤后部分（但非全部）行为任务中的自发活动升高。相比之下，较高的利培酮预处理在预防新生儿海马损伤后自发活动升高方面效果较差。由于在人类研究中也发现低剂量的利培酮可有效预防首发精神病，因此这些数据支持海马损伤模型在识别预防首发精神病药物方面的预测有效性。此外，这些数据支持使用低剂量利培酮预防精神病，并表明更高剂量的利培酮可能在此应用中效果较差。
Long-standing behavioral abnormalities emerge after puberty in rats following neonatal hippocampal lesion, providing a developmental model of abnormal rat behavior that may have predictive validity in identifying compounds effective in treating symptoms of schizophrenia. We sought to test the predictive validity of the neonatal hippocampal lesion model in identifying preventive treatment for first-episode psychosis. We determined the effect of risperidone, recently studied for prevention of first-episode psychosis, on the development of elevated locomotor activity following neonatal hippocampal lesions. Rat pups received hippocampal or sham lesions on postnatal day 7, followed by treatment with risperidone or vehicle from postnatal days 35 to 56. Locomotor activity in response to novelty, amphetamine, and nocturnal locomotion were determined on postnatal day 57. Low-dose risperidone (45 μg/kg) pretreatment prevented elevated locomotor activity in some, but not all, of the behavioral tasks following neonatal hippocampal lesions. In contrast, higher risperidone pretreatment was less effective in preventing elevated locomotor activity following neonatal hippocampal lesions. Because low risperidone dosages were also found to be effective in preventing first-episode psychosis in human studies, these data support the predictive validity of the hippocampal lesion model in identifying medications for prevention of first-episode psychosis. Additionally, these data support the use of low-dose risperidone in psychosis prevention, and suggest the possibility that higher risperidone doses could be less effective in this application.
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DOI：
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发表时间：
1981
期刊：
American journal of medical genetics
影响因子：
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DOI：
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发表时间：
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期刊：
Acta geneticae medicae et gemellologiae
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作者：
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影响因子：
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