Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage.
Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage.
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DOI：
10.1289/ehp.1002238
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发表时间：
2011-02
影响因子：
10.4
通讯作者：
Hauser R
中科院分区：
文献类型：
--
作者：
Meeker JD;Yang T;Ye X;Calafat AM;Hauser R
对羟基苯甲酸酯通常用作化妆品、药品以及食品和饮料加工中的抗菌防腐剂。最近有记录表明，人类广泛接触对羟基苯甲酸酯，并且在动物研究中，一些对羟基苯甲酸酯已被证明对男性生殖产生不利影响。然而，缺乏人类流行病学研究。我们在一项正在进行的生殖流行病学研究中调查了尿液中对羟基苯甲酸酯浓度与男性生殖健康标志物之间的关系。对从不孕不育诊所就诊的男性伴侣收集的尿液样本进行了对羟基苯甲酸甲酯 (MP)、对羟基苯甲酸丙酯 (PP)、对羟基苯甲酸丁酯 (BP) 和双酚 A (BPA) 的分析。使用多元线性回归评估与血清激素水平 (n = 167)、精液质量参数 (n = 190) 和精子 DNA 损伤测量值 (n = 132) 的关联。尿液中 MP 检出率为 100%，PP 检出率为 92%，BP 检出率为 32%。我们观察到 MP 或 PP 与结果测量之间没有统计学上的显着关联。尿血压浓度的类别与激素水平或常规精液质量参数无关，但与精子 DNA 损伤呈正相关（趋势 p = 0.03）。当将尿液 BPA 四分位数添加到模型中时，BP 和 BPA 均与精子 DNA 损伤呈正相关（趋势 p = 0.03）。对一部分男性 (n = 78) 的重复尿液样本测量的对羟基苯甲酸酯浓度进行评估，发现存在显着的时间变异性。我们没有发现尿液中对羟基苯甲酸酯与激素水平或精液质量之间存在关系的证据，尽管个体暴露的差异和适度的样本量可能限制了我们检测微妙关系的能力。我们对 BP 与精子 DNA 损伤之间关系的观察值得进一步研究。
Parabens are commonly used as antimicrobial preservatives in cosmetics, pharmaceuticals, and food and beverage processing. Widespread human exposure to parabens has been recently documented, and some parabens have demonstrated adverse effects on male reproduction in animal studies. However, human epidemiologic studies are lacking. We investigated relationships between urinary concentrations of parabens and markers of male reproductive health in an ongoing reproductive epidemiology study. Urine samples collected from male partners attending an infertility clinic were analyzed for methyl paraben (MP), propyl paraben (PP), butyl paraben (BP), and bisphenol A (BPA). Associations with serum hormone levels (n = 167), semen quality parameters (n = 190), and sperm DNA damage measures (n = 132) were assessed using multivariable linear regression. Detection rates in urine were 100% for MP, 92% for PP, and 32% for BP. We observed no statistically significant associations between MP or PP and the outcome measures. Categories of urinary BP concentration were not associated with hormone levels or conventional semen quality parameters, but they were positively associated with sperm DNA damage (p for trend = 0.03). When urinary BPA quartiles were added to the model, BP and BPA were both positively associated with sperm DNA damage (p for trend = 0.03). Assessment of paraben concentrations measured on repeated urine samples from a subset of the men (n = 78) revealed substantial temporal variability. We found no evidence for a relationship between urinary parabens and hormone levels or semen quality, although intraindividual variability in exposure and a modest sample size could have limited our ability to detect subtle relationships. Our observation of a relationship between BP and sperm DNA damage warrants further investigation.
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影响因子：
4.3
作者：
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