Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.
Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.
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DOI：
10.1002/osp4.511
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发表时间：
2021-08
影响因子：
2.2
通讯作者：
Mariani TJ
中科院分区：
文献类型：
--
作者：
Meng Y;Groth SW;Hodgkinson CA;Mariani TJ
在动物模型中，中枢和外周5-羟色胺系统在调节能量平衡和肥胖发展中的重要性已经得到强调。然而，这两种血清素系统的作用尚未在人类中进行系统评估。本研究的目的是调查两个血清素系统内的基因与黑人青少年肥胖结果的关联。非裔美国青少年（n = 1052）的母亲参加了孟菲斯新母亲的研究进行了评估。总的来说，110个多态性映射到10个5-羟色胺基因进行了检查，其与标准化体重指数（BMI-z）评分和腰围使用广义估计方程模型的关联。超过39%的青少年超重或肥胖。TPH 2、HTR 3B和SLC 6A 4中的三个单核苷酸多态性（SNP）与BMI-z评分显著相关（p < 1.7 × 10−3）。TPH 2中的两个SNPs名义上与腰围相关。HTR 2C中的一个SNP仅在女孩中与BMI-z评分（p = 0.001）和腰围（p = 0.005）相关。组织特异性表达表明三种鉴定的基因主要在脑中表达。中枢5-羟色胺系统可能在黑人青少年肥胖发展中起关键作用。未来的研究是必要的，以探索其他的5-羟色胺系统基因和他们的潜在的致肥胖机制在人类。
The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents. African–American adolescents (n = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI‐z) scores and waist circumferences using generalized estimating equation models. Over 39% of adolescents were overweight or had obesity. Three single nucleotide polymorphisms (SNPs) within TPH2, HTR3B, and SLC6A4, were significantly associated with BMI‐z scores (p < 1.7 × 10−3). Two SNPs in TPH2 were nominally associated with waist circumferences. One SNP in HTR2C was associated with BMI‐z scores (p = 0.001) and waist circumferences (p = 0.005) only in girls. Tissue‐specific expression indicates that three identified genes are predominantly expressed in the brain. The central serotonin system may play a key role in obesity development in black adolescents. Future studies are warranted to explore additional serotonin system genes and their potential obesogenic mechanisms in humans.
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影响因子：
3
作者：
Dias, Helena;Muc, Magdalena;Manco, Licinio
通讯作者：
Manco, Licinio
影响因子：
5.6
作者：
Miranda, Raquel C. K.;Genro, Julia P.;Almeida, Silvana
通讯作者：
Almeida, Silvana
影响因子：
4.9
作者：
Hinney, A;Herrmann, H;Hebebrand, J
通讯作者：
Hebebrand, J
影响因子：
6.9
作者：
Kwak, Soo Heon;Park, Byoung Lae;Park, Kyong Soo
通讯作者：
Park, Kyong Soo
影响因子：
5
作者：
Edwards, Todd L.;Edwards, Digna R. Velez;Matthews, Charles E.
通讯作者：
Matthews, Charles E.