Did Convergent Protein Evolution Enable Phytoplasmas to Generate 'Zombie Plants'?

Did Convergent Protein Evolution Enable Phytoplasmas to Generate 'Zombie Plants'?
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趋同蛋白进化是否使植原体能够产生“僵尸植物”?

DOI:
10.1016/j.tplants.2015.08.004
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发表时间:
2015
影响因子:
20.5
通讯作者:
Melzer
Melzer
中科院分区:
生物学1区
文献类型:
--
作者:
Rümpler;Gramzow;Theißen;Melzer

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植原体是一种病原菌,它对植物的发育进行重新编程,使植物发育成叶状结构,而不是花器官。受感染的植物是不育的,主要用来繁殖植原体,因此被称为“僵尸植物”。发育重编程依赖于植原体蛋白SAP54与MADS结构域转录因子的一小部分的特定相互作用。在这里,我们认为SAP54折叠成一个类似于K-结构域的结构,K-结构域是MADS-结构域蛋白质的一个蛋白质-蛋白质相互作用结构域。我们认为,经过趋同的结构和序列进化,SAP54进化为模拟K-结构域。鉴于由此产生的发育变化的高度特异性,植质体可能被用于研究遗传上难以处理的植物的花发育。
Phytoplasmas are pathogenic bacteria that reprogram plant development such that leaf-like structures instead of floral organs develop. Infected plants are sterile and mainly serve to propagate phytoplasmas and thus have been termed ‘zombie plants'. The developmental reprogramming relies on specific interactions of the phytoplasma protein SAP54 with a small subset of MADS-domain transcription factors. Here, we propose that SAP54 folds into a structure that is similar to that of the K-domain, a protein–protein interaction domain of MADS-domain proteins. We suggest that undergoing convergent structural and sequence evolution, SAP54 evolved to mimic the K-domain. Given the high specificity of resulting developmental alterations, phytoplasmas might be used to study flower development in genetically intractable plants.
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