The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature.

The role of diet and physical activity in breast, colorectal, and prostate cancer survivorship: a review of the literature.
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DOI:
10.1038/bjc.2011.423
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发表时间:
2011-11-08
影响因子:
8.8
通讯作者:
Thomas, R.
Thomas, R.
中科院分区:
医学1区
文献类型:
--
作者:
Davies, N. J.;Batehup, L.;Thomas, R.

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饮食和身体活动在癌症发病率中的作用的证据已有充分记录,但由于癌症存活率增加,在癌症诊断后了解这些生活方式因素至关重要。本次综述的目的是更新国家癌症生存计划综述中的文献,并纳入 WCRF 生存系统评价中未包含的观察性研究。证据最初是从 2006 年 3 月至 2010 年 2 月对 Cochrane 图书馆数据库和 PubMed 的预定义搜索中收集的。在对生活方式和癌症进行全面审查后,出于本文的目的,排除了与饮食和身体活动、预后结果以及乳腺癌、结直肠癌或前列腺癌无关的任何研究。对2011年的文献进行了另一次检索以更新证据。本次审核共纳入43条记录。观察性研究的证据表明,低脂肪、高纤维饮食可能可以预防癌症复发和进展。然而,很少有随机对照试验证实这一点。对身体活动有更多支持,并通过剂量反应获得更好的结果。世界癌症研究基金会对研究饮食和身体活动干预措施对癌症生存影响的随机对照试验的审查结果综合起来,有证据表明,饮食和身体活动的获益机制与体重有关,体重过重是一个危险因素,可以通过生活方式改变。癌症幸存者希望在医疗保健中发挥更积极的作用,并了解诊断后如何照顾自己,包括他们应该改变饮食和生活方式。挑战在于将生活方式支持整合到标准化的善后护理模式中。
Evidence for the role of diet and physical activity in cancer incidence is well documented, but owing to increased cancer survivorship, an understanding of these lifestyle factors after a cancer diagnosis is of crucial importance. The purpose of this review was to update the literature in a review undertaken for the National Cancer Survivorship Initiative and to include observational studies that were not included in the WCRF survivorship systematic review. Evidence was initially gathered from pre-defined searches of the Cochrane Library Database and PubMed from March 2006 to February 2010. After a comprehensive review regarding lifestyle and cancer, for the purpose of this article, any studies not related to diet and physical activity, prognostic outcomes, and breast, colorectal or prostate cancers were excluded. Another search of 2011 literature was conducted to update the evidence. A total of 43 records were included in this review. Evidence from observational studies suggests that a low-fat, high-fibre diet might be protective against cancer recurrence and progression. However, there is a paucity of RCTs substantiating this. There is more support for physical activity, with a dose response for better outcomes. When synthesized with findings from the World Cancer Research Fund review of RCTs investigating the effect of diet and physical activity interventions on cancer survival, evidence suggests that the mechanism of benefit from diet and physical activity pertains to body weight, with excess body weight being a risk factor, which is modifiable through lifestyle. Cancer survivors would like to have a more active role in their health care and to know how to look after themselves after diagnosis, including what diet and lifestyle changes they should make. The challenge is in integrating lifestyle support into standardised models of aftercare.
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