Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus.
Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus.
复制标题
DOI：
10.1037/bne0000388
复制
发表时间：
2020-12
影响因子：
1.9
通讯作者：
Holmes GL
中科院分区：
文献类型：
--
作者：
Barry JM;Mahoney JM;Holmes GL
认知缺陷可能由多种遗传改变和神经损伤引起，损害神经编码机制和支持学习和记忆的神经信息的路由。缓慢和中等的伽马振荡支持记忆回忆和感觉运动加工，并代表CA1突触的动态输入。发热性癫痫持续状态（FSE）可导致颞叶癫痫和持久认知障碍的风险增加。在啮齿动物模型中，我们评估了FSE如何改变与空间任务表现相关的海马CA1信号，并作为突触输入效能的读数。在旋转舞台上主动回避行为中，theta （5 - 12hz）、慢伽马（30 - 50hz）和中伽马（70 - 90hz）的功率在认知需求方面存在差异。成功回避的特征是在峰值加速之前或之后的几秒钟内伽马值最大。加速度峰值与θ振荡峰值重合，随后在大约1秒内出现中伽马峰值。在任务中表现出损伤的FSE动物在峰值加速后保持了与感觉运动加工增加相关的θ波和中伽马谱，但没有表现出与记忆检索时期相关的相同的慢伽马谱。虽然来自内嗅皮质的CA1突触在功能上不受FSE的影响，但通过来自CA3突触的通信可能已经受损，导致时间协调失调和记忆恢复不良。这些发现表明，theta/gamma谱既可以作为记忆恢复或编码缺陷的生理生物标志物，也可以作为突触水平的治疗靶点，可以减轻与早期癫痫发作相关的认知合并症。
Cognitive deficits may arise from a variety of genetic alterations and neurological insults that impair neural coding mechanisms and the routing of neural information underpinning learning and memory. Slow and medium gamma oscillations underpin memory recall and sensorimotor processing and represent dynamic inputs at CA1 synapses. Febrile status epilepticus (FSE) can lead to increased risk for temporal lobe epilepsy and enduring cognitive impairments. In a rodent model, we assessed how FSE alters hippocampal CA1 signals relative to spatial task performance and serve as a readout of synaptic input efficacy. The power of theta (5–12 Hz), slow gamma (30–50 Hz), and medium gamma (70–90 Hz) differentially interact with respect to cognitive demands during active avoidance behavior on a rotating arena. Successful avoidance was characterized by slow gamma that was largest several seconds before or after peak acceleration. Peak acceleration coincides with peak theta oscillations, followed within approximately 1 s by peak medium gamma. FSE animals showing impairment in the task maintained the profiles of theta and medium gamma associated with increased sensorimotor processing following peak acceleration but did not exhibit the same slow gamma profile associated with epochs of memory retrieval. While CA1 synapses from entorhinal cortex were functionally unaffected by FSE, communication via synapses from CA3 may have been impaired, leading to both temporal discoordination and poor memory retrieval. These findings demonstrate theta/gamma profiles can serve as both physiological biomarkers for memory retrieval or encoding deficits and synapse level treatment targets that could attenuate cognitive comorbidities associated with early life seizures.
登录
查看更多内容
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
5.4
作者：
Brennan GP;Baram TZ;Poolos NP
通讯作者：
Poolos NP
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
DOI：
10.1523/jneurosci.5110-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ahmed OJ;Mehta MR
通讯作者：
Mehta MR
影响因子：
5.3
作者：
Barry, Jeremy M.;Choy, ManKin;Dube, Celine;Robbins, Ashlee;Obenaus, Andre;Lenck-Santini, Pierre Pascal;Scott, Rod C.;Baram, Tallie Z.;Holmes, Gregory L.
通讯作者：
Holmes, Gregory L.