Evaluation of Renal Blood Flow in Chronic Kidney Disease Using Arterial Spin Labeling Perfusion Magnetic Resonance Imaging.
Evaluation of Renal Blood Flow in Chronic Kidney Disease Using Arterial Spin Labeling Perfusion Magnetic Resonance Imaging.
复制标题
使用动脉自旋标记灌注磁共振成像评估慢性肾脏疾病中的肾血流。
DOI：
10.1016/j.ekir.2016.09.003
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发表时间：
2017-01
影响因子：
6
通讯作者：
Prasad PV
中科院分区：
文献类型：
--
作者：
Li LP;Tan H;Thacker JM;Li W;Zhou Y;Kohn O;Sprague SM;Prasad PV
众所周知，慢性肾脏疾病（CKD）与肾血流量减少有关。然而，迄今为止，人类的数据有限。在这项研究中，我们获得了33名糖尿病和3期CKD患者以及30名健康对照者的无创动脉自旋标记磁共振成像数据。肾皮质血流量（108.4±36.4比207.3±41.8,P < 0.001, d = 2.52）和髓质血流量（23.2±8.9比42.6±15.8,P < 0.001, d = 1.5）均明显降低。皮质血流量（ρ = 0.67, P < 0.001）和髓质血流量（ρ = 0.62, P < 0.001）均与肾小球滤过率相关，且发现皮质血流量与年龄和体重指数相混淆。然而，在年龄和体重指数匹配的一部分受试者中（n = 6）， CKD患者与对照组在皮质（107.4±42.8 vs. 187.51±20.44;P = 0.002）和髓质（15.43±8.43 vs. 39.18±11.13;P = 0.002）的差异仍然显著。区分健康对照和CKD患者的阈值估计为皮质血流量142.9和髓质血流量24.1。这些结果支持动脉自旋标记在评估中度CKD患者肾血流中的应用。这些测量是否可以识别有进展性CKD风险的患者需要进一步的纵向随访。
Chronic kidney disease (CKD) is known to be associated with reduced renal blood flow. However, data in humans are limited to date. In this study, noninvasive arterial spin labeling magnetic resonance imaging data were acquired in 33 patients with diabetes and stage 3 CKD as well as in 30 healthy controls. A significantly lower renal blood flow in both the cortex (108.4 ± 36.4 vs. 207.3 ± 41.8; P < 0.001, d = 2.52) and medulla (23.2 ± 8.9 vs. 42.6 ± 15.8; P < 0.001, d = 1.5) was observed. Both cortical (ρ = 0.67, P < 0.001) and medullary (ρ = 0.62, P < 0.001) blood flow were correlated with estimated glomerular filtration rate, and cortical blood flow was found to be confounded by age and body mass index. However, in a subset of subjects who were matched for age and body mass index (n = 6), the differences between CKD patients and control subjects remained significant in both the cortex (107.4 ± 42.8 vs. 187.51 ± 20.44; P = 0.002) and medulla (15.43 ± 8.43 vs. 39.18 ± 11.13; P = 0.002). A threshold value to separate healthy controls and CKD patients was estimated to be a cortical blood flow of 142.9 and a medullary blood flow of 24.1. These results support the use of arterial spin labeling in the evaluation of renal blood flow in patients with a moderate level of CKD. Whether these measurements can identify patients at risk for progressive CKD requires further longitudinal follow-up.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.3
作者：
Ordidge, RJ;Wylezinska, M;Franconi, F
通讯作者：
Franconi, F
动脉自旋标记MRI用于评估天然和移植肾脏的灌注。
影响因子：
2.5
作者：
Artz, Nathan S.;Sadowski, Elizabeth A.;Wentland, Andrew L.;Grist, Thomas M.;Seo, Songwon;Djamali, Arjang;Fain, Sean B.
通讯作者：
Fain, Sean B.
影响因子：
1.6
作者：
Hammon M;Janka R;Siegl C;Seuss H;Grosso R;Martirosian P;Schmieder RE;Uder M;Kistner I
通讯作者：
Kistner I
影响因子：
3.3
作者：
Duiardin, Martine;Luypaert, Rob;de Mey, Johan
通讯作者：
de Mey, Johan