Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults: An Interventional Trial.
Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults: An Interventional Trial.
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盐摄入量对中国成人血浆和尿尿酸水平的影响：一项干预性试验
DOI：
10.1038/s41598-018-20048-2
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发表时间：
2018-01-23
影响因子：
4.6
通讯作者：
Mu JJ
中科院分区：
文献类型：
--
作者：
Wang Y;Chu C;Wang KK;Hu JW;Yan Y;Lv YB;Cao YM;Zheng WL;Dang XL;Xu JT;Chen W;Yuan ZY;Mu JJ
尿酸(UA)已被认为是心血管和肾脏疾病发病率的重要危险因素。我们进行了一项干预性试验，以评估盐摄入量改变对人类血浆和尿尿酸水平的影响，以及尿酸水平与盐敏感性的关系。90名年龄在18-65岁的受试者被依次维持在基线水平的正常饮食3天，低盐饮食7天(3.0 g/天，氯化钠)，以及高盐饮食7天(18.0 g/天氯化钠)。血浆UA水平从低盐饮食到低盐饮食显著升高，从低盐饮食到高盐饮食显著下降。相比之下，每日尿尿酸水平从基线到低盐饮食显著下降，从低盐饮食到高盐饮食增加。24 h尿钠排泄量与血浆UA呈负相关，与尿UA排泄量呈正相关。此外，盐敏感者的血浆UA变化显著高于耐盐者，且盐敏感程度与血浆UA差值呈负相关。本研究提示，膳食盐摄入量的变化影响血、尿UA水平，血浆UA可能参与盐敏感性的病理生理过程。
Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Ninety subjects (18–65 years old) were sequentially maintained on a normal diet for 3 days at baseline, a low-salt diet for 7 days (3.0 g/day, NaCl), and a high-salt diet for an additional 7 days (18.0 g/day of NaCl). Plasma UA levels significantly increased from baseline to low-salt diet and decreased from low-salt to high-salt diet. By contrast, daily urinary levels of UA significantly decreased from baseline to low-salt diet and increased from low-salt to high-salt diet. The 24 h urinary sodium excretions showed inverse correlation with plasma UA and positive correlation with urinary UA excretions. Additionally, salt-sensitive subjects presented significantly higher plasma UA changes in comparison to salt-resistant subjects, and a negative correlation was observed between degree of salt sensitivity and plasma UA difference. The present study indicates that variations in dietary salt intake affect plasma and urine UA levels, and plasma UA may be involved in pathophysiological process of salt sensitivity.
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DOI：
10.1016/j.jash.2016.10.012
发表时间：
2016-12
期刊：
Journal of the American Society of Hypertension : JASH
影响因子：
--
作者：
Juraschek SP;Choi HK;Tang O;Appel LJ;Miller ER 3rd
通讯作者：
Miller ER 3rd
影响因子：
20.1
作者：
O'Donnell, Martin;Mente, Andrew;Yusuf, Salim
通讯作者：
Yusuf, Salim
绝经和激素替代疗法对高尿酸血症与死亡率关联的影响。
影响因子：
5.3
作者：
Ioannou GN;Boyko EJ
通讯作者：
Boyko EJ
DOI：
10.1002/art.39813
发表时间：
2016-12
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Juraschek SP;Gelber AC;Choi HK;Appel LJ;Miller ER 3rd
通讯作者：
Miller ER 3rd
影响因子：
3.2
作者：
EGAN, BM;WEDER, AB;HOFFMAN, RG
通讯作者：
HOFFMAN, RG