Estimation of dietary iron bioavailability from food iron intake and iron status.
Estimation of dietary iron bioavailability from food iron intake and iron status.
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DOI：
10.1371/journal.pone.0111824
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Fairweather-Tait SJ
中科院分区：
文献类型：
--
作者：
Dainty JR;Berry R;Lynch SR;Harvey LJ;Fairweather-Tait SJ
目前还没有令人满意的方法来估计人群水平的膳食铁吸收(生物利用度)，但这对于使用析因法得出膳食参考值是必不可少的。这项工作的目的是开发一种新的方法，利用英国国家饮食和营养调查(NDNS)的一个子部分的人口样本来估计膳食铁的吸收。分析了2000年至2001年NDNS成人队列中的873名受试者的数据，这些受试者的饮食摄入数据和血液学指标(血红蛋白和血清铁蛋白(SF)浓度)都是可用的。其中男性495例，年龄19-，平均年龄42.7±12.1岁；绝经前女性378例，平均年龄35.7±8.2岁。每个人的膳食铁需求量是使用医学研究所的计算来估计的。然后应用全概率方法，根据男性和女性估计的每日铁摄入量和从1-40%范围内的一系列吸收率，分别估计不足以满足男性和女性需要的饮食摄入量的流行率。SF浓度低于选定的截止值(表明吸收程度不足以维持铁的储存)的流行程度是由单个SF浓度得出的。然后，通过将观察到的铁缺乏患病率与一系列吸收估计的预测患病率进行匹配，计算出维持特定SF值所需的膳食铁吸收估计值。男性平均每日膳食铁摄入量为13.5毫克，女性为9.8毫克。平均计算的膳食吸收率男性为8%(SF85微克/L为第50百分位数)，女性为17%(SF38微克/L为第50百分位数)。在铁蛋白水平为45微克/L时，男性(14%)和女性(13%)的估计吸收情况相似。这种新方法可以使用描述总铁摄入量和SF浓度的数据来计算人群水平的膳食铁吸收。
Currently there are no satisfactory methods for estimating dietary iron absorption (bioavailability) at a population level, but this is essential for deriving dietary reference values using the factorial approach. The aim of this work was to develop a novel approach for estimating dietary iron absorption using a population sample from a sub-section of the UK National Diet and Nutrition Survey (NDNS). Data were analyzed in 873 subjects from the 2000–2001 adult cohort of the NDNS, for whom both dietary intake data and hematological measures (hemoglobin and serum ferritin (SF) concentrations) were available. There were 495 men aged 19–64 y (mean age 42.7±12.1 y) and 378 pre-menopausal women (mean age 35.7±8.2 y). Individual dietary iron requirements were estimated using the Institute of Medicine calculations. A full probability approach was then applied to estimate the prevalence of dietary intakes that were insufficient to meet the needs of the men and women separately, based on their estimated daily iron intake and a series of absorption values ranging from 1–40%. The prevalence of SF concentrations below selected cut-off values (indicating that absorption was not high enough to maintain iron stores) was derived from individual SF concentrations. An estimate of dietary iron absorption required to maintain specified SF values was then calculated by matching the observed prevalence of insufficiency with the prevalence predicted for the series of absorption estimates. Mean daily dietary iron intakes were 13.5 mg for men and 9.8 mg for women. Mean calculated dietary absorption was 8% in men (50th percentile for SF 85 µg/L) and 17% in women (50th percentile for SF 38 µg/L). At a ferritin level of 45 µg/L estimated absorption was similar in men (14%) and women (13%). This new method can be used to calculate dietary iron absorption at a population level using data describing total iron intake and SF concentration.
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影响因子：
3.6
作者：
Harvey, LJ;Armah, CN;Fairweather-Tait, SJ
通讯作者：
Fairweather-Tait, SJ
影响因子：
7.1
作者：
Hunt, Janet R.;Zito, Carol Ann;Johnson, LuAnn K.
通讯作者：
Johnson, LuAnn K.
影响因子：
7.1
作者：
COOK, JD;DASSENKO, SA;LYNCH, SR
通讯作者：
LYNCH, SR
影响因子：
7.1
作者：
Hallberg, L;Hulten, L;Gramatkovski, E
通讯作者：
Gramatkovski, E
影响因子：
4.7
作者：
Hallberg, L;Hulthen, L;Garby, L
通讯作者：
Garby, L