The Specificity of Inhibitory Control Deficits in Post-Traumatic Stress Disorder: A Dissociation Between the Speed and Reliability of Stopping.
The Specificity of Inhibitory Control Deficits in Post-Traumatic Stress Disorder: A Dissociation Between the Speed and Reliability of Stopping.
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DOI：
10.1016/j.janxdis.2020.102278
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发表时间：
2020-10
影响因子：
10.3
通讯作者：
Ashley V
中科院分区：
文献类型：
--
作者：
Swick D;Ashley V
对于患有创伤后应激障碍（PTSD）的人来说，对思想、情绪和行为的抑制性控制是一项挑战。抑制控制的特定方面是否在PTSD中受到不同的影响仍然是一个悬而未决的问题。在这里，我们研究了两个流行的反应抑制任务的表现在28个战斗退伍军人与创伤后应激障碍和27个控制退伍军人。我们使用了混合变体，混合了75%的Go试验，12.5%的NoGo试验和12.5%的Stop试验。来自前高斯竞赛模型的参数（Matzke，Love和Heathcote，2017）提供了停止速度（μ Stop）和停止变异性（τ Stop）的估计值。PTSD参与者在NoGo试验中的错误率更高，复制了以前的结果。在PTSD患者中，停止试验中“触发失败”（未能启动抑制控制）的估计概率也较高，这表明持续的注意力是这两项任务中的常见缺陷。PTSD参与者的停止变异性也增加了，这支持了维持任务目标的困难。相反，患者和对照组之间的停止速度没有差异，表明核心抑制过程是完整的。这些结果表明PTSD运动反应抑制的速度和可靠性之间的分离，并表明自上而下的抑制控制在PTSD参与者中的部署不太一致。
Inhibitory control over thoughts, emotions, and actions is challenging for people with Post-Traumatic Stress Disorder (PTSD). Whether specific aspects of inhibitory control are differentially affected in PTSD remains an open question. Here we examined performance on two popular response inhibition tasks in 28 combat Veterans with PTSD and 27 control Veterans. We used a Hybrid variant that intermixed 75% Go trials, 12.5% NoGo trials, and 12.5% Stop trials. Parameters from an ex-Gaussian race model (Matzke, Love, & Heathcote, 2017) provided estimates of stopping speed (μ Stop) and stopping variability (τ Stop). Participants with PTSD had higher error rates on NoGo trials, replicating previous results. The estimated probability of “trigger failures” (failures to launch inhibitory control) on Stop trials was also higher in PTSD patients, suggesting that sustained attention was a common deficit in the two tasks. Stopping variability was also increased in participants with PTSD, which supports a difficulty with maintaining task goals. Conversely, stopping speed did not differ between patients and controls, suggesting that core inhibitory processes were intact. These results demonstrate a dissociation between the speed and reliability of motor response inhibition in PTSD, and suggest that top-down inhibitory control was deployed less consistently in participants with PTSD.
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影响因子：
3.6
作者：
Jovanovic, Tanja;Ely, Tim;Fani, Negar;Glover, Ebony M.;Gutman, David;Tone, Erin B.;Norrholm, Seth D.;Bradley, Bekh;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
DOI：
10.3758/s13414-017-1287-8
发表时间：
2017-05
期刊：
Attention, perception & psychophysics
影响因子：
--
作者：
Matzke D;Hughes M;Badcock JC;Michie P;Heathcote A
通讯作者：
Heathcote A
影响因子：
4.7
作者：
Aupperle RL;Melrose AJ;Stein MB;Paulus MP
通讯作者：
Paulus MP
影响因子：
10.6
作者：
Aron, AR;Poldrack, RA
通讯作者：
Poldrack, RA
影响因子：
8.2
作者：
Logan, GD;Schachar, RJ;Tannock, R
通讯作者：
Tannock, R