Hippocampal cells encode places by forming small anatomical clusters.
Hippocampal cells encode places by forming small anatomical clusters.
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DOI：
10.1016/j.neuroscience.2009.12.069
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发表时间：
2010-03-31
期刊：
影响因子：
3.3
通讯作者：
Pavlides, C.
中科院分区：
文献类型：
--
作者：
Nakamura, N. H.;Fukunaga, M.;Akama, K. T.;Soga, T.;Ogawa, S.;Pavlides, C.
海马被认为是一个“空间”或“认知”的地图，然而，空间地图的功能细胞组织仍然是一个谜。迄今为止，大多数电生理学研究都支持海马中随机型组织的观点。然而，使用立即早期基因（IEGs）作为神经元活动的指标，我们最近观察到海马主细胞的簇型组织，其中少数（~4）附近的细胞被激活的动物暴露于有限的部分环境。为了确定这些簇的精细结构，并提供编码环境不同部分的活性海马细胞的3D图像，我们使用原位杂交和3D重建成像方法建立了立即早期基因（IEGs）zif 268和Homer 1a的功能图谱。我们发现，与暴露于两个不同位置的动物相比，在暴露于同一位置两次的动物中，有更多的双IEG表达细胞，并且附近细胞的簇形成得更“紧密”。我们认为，空间编码招募特定的细胞合奏在海马和反复暴露于同一个地方的合奏变得更好地组织，更准确地代表“空间地图”。
The hippocampus has been hypothesized to function as a “spatial” or “cognitive” map, however, the functional cellular organization of the spatial map remains a mystery. The majority of electrophysiological studies, thus far, have supported the view of a random-type organization in the hippocampus. However, using immediate early genes (IEGs) as an indicator of neuronal activity, we recently observed a cluster-type organization of hippocampal principal cells, whereby a small number (~4) of nearby cells were activated in animals exposed to a restricted part of an environment. To determine the fine structure of these clusters and to provide a 3D image of active hippocampal cells that encode for different parts of an environment, we established a functional mapping of immediate early genes (IEGs) zif268 and Homer1a, using in situ hybridization and 3D-reconstruction imaging methods. We found that, in animals exposed to the same location twice, there were significantly more double IEG-expressing cells, and the clusters of nearby cells were more “tightly” formed, in comparison to animals exposed to two different locations. We propose that spatial encoding recruits specific cell ensembles in the hippocampus and that with repeated exposure to the same place the ensembles become better organized to more accurately represent the “spatial map”.
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DOI：
10.1073/pnas.0308577100
发表时间：
2004-02-24
影响因子：
11.1
作者：
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影响因子：
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作者：
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