Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations.
Frailty in Older Adults Is Associated With Plasma Concentrations of Inflammatory Mediators but Not With Lymphocyte Subpopulations.
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DOI：
10.3389/fimmu.2018.01056
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发表时间：
2018
影响因子：
7.3
通讯作者：
Valdiglesias V
中科院分区：
文献类型：
--
作者：
Marcos-Pérez D;Sánchez-Flores M;Maseda A;Lorenzo-López L;Millán-Calenti JC;Gostner JM;Fuchs D;Pásaro E;Laffon B;Valdiglesias V
虚弱是一种多维综合征，导致对压力源的脆弱性，并导致不同生理系统和认知能力的年龄相关性下降增加。免疫系统的老化相关改变可能会损害其能力，最终导致慢性低度炎症状态。因此，已经提出虚弱与促炎分子浓度和不同淋巴细胞亚群中的改变有关。为了进一步支持这一假设的有效性，我们进行了一项横断面研究，在西班牙老年人（N = 259，年龄65岁及以上）根据他们的脆弱状态分类的人口。分析的生物标志物包括几种淋巴细胞亚群和几种炎症介质的百分比，即白细胞介素6（IL 6）、C反应蛋白（CRP）、肿瘤坏死因子α（TNFα）和75 kDa可溶性TNFα受体II（sTNF-RII）的浓度。首次在健康老年人中建立了炎症介质的参考范围。在虚弱组中观察到CD 4 +/CD 8+比值显著增加，%CD 19+细胞显著降低。所有炎症介质浓度均随虚弱严重程度进行性增加，尤其是IL 6和sTNF-RII。sTNF-RII的受试者工作特征曲线下面积（0.90，95%CI 0.85-0.94，P < 0.001）表明该生物标志物对虚弱的预测价值具有较高的准确性。虽然目前的研究结果显示虚弱和评估的淋巴细胞亚群之间的关联有限，但获得的炎症介质数据进一步支持了老年人虚弱状态中炎症的参与。
Frailty denotes a multidimensional syndrome that gives rise to vulnerability to stressors and leads to an increase of the age-related decline of different physiological systems and cognitive abilities. Aging-related alterations of the immune system may compromise its competence culminating in a chronic low-grade inflammation state. Thus, it has been proposed that frailty is associated with alterations in the concentration of pro-inflammatory molecules and in different lymphocyte subpopulations. To provide further support to the validity of that hypothesis, we conducted a cross-sectional study in a population of Spanish older adults (N = 259, aged 65 and over) classified according to their frailty status. Biomarkers analyzed included percentages of several lymphocyte subsets and several inflammation mediators, namely concentrations of interleukin 6 (IL6), C-reactive protein (CRP), tumor necrosis factor α (TNFα), and 75 kDa soluble TNFα receptor II (sTNF-RII). Reference ranges for the inflammation mediators were established for the first time in robust older adults. A significant increase in the CD4+/CD8+ ratio and a significant decrease in the % CD19+ cells were observed in the frail group. Progressive increases with frailty severity were obtained in all inflammatory mediator concentrations, especially notable for IL6 and sTNF-RII. Area under the receiver-operating characteristic curve obtained for sTNF-RII (0.90, 95% CI 0.85–0.94, P < 0.001) indicates a high accuracy in the predictive value of this biomarker for frailty. Although results from the current study revealed limited strength associations between frailty and the lymphocyte subsets assessed, data obtained for the inflammatory mediators provide further support to involvement of inflammaging in frailty status in older adults.
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影响因子：
6.3
作者：
Giovannini S;Onder G;Liperoti R;Russo A;Carter C;Capoluongo E;Pahor M;Bernabei R;Landi F
通讯作者：
Landi F
DOI：
10.1111/j.1532-5415.2008.01673.x
发表时间：
2008-05-01
影响因子：
6.3
作者：
De Fanis, Umberto;Wang, George C.;Leng, Sean X.
通讯作者：
Leng, Sean X.
影响因子：
--
作者：
Liu, Christine K.;Lyass, Asya;Murabito, Joanne M.
通讯作者：
Murabito, Joanne M.
影响因子：
5.8
作者：
Garcia-Garcia, F. J.;Gutierrez Avila, G.;Rodriguez-Manas, L.
通讯作者：
Rodriguez-Manas, L.
影响因子：
27.4
作者：
Grivennikov, Sergei I.;Karin, Michael
通讯作者：
Karin, Michael