Graphene/barium titanate/polymethyl methacrylate bio-piezoelectric composites for biomedical application
Graphene/barium titanate/polymethyl methacrylate bio-piezoelectric composites for biomedical application
复制标题
石墨烯/钛酸钡/聚甲基丙烯酸甲酯生物压电复合材料的生物医学应用
DOI：
10.1016/j.ceramint.2019.11.142
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发表时间：
2020-04
影响因子：
5.2
通讯作者：
Zixiang Wu
中科院分区：
文献类型：
--
作者：
Yufei Tang;Lei Chen;Zihao Duan;Kang Zhao;Zixiang Wu
将BaTiO3(BT)粒子引入到聚甲基丙烯酸甲酯(PMMA)骨水泥等生物材料中，是提高其骨诱导活性的有效途径之一。然而，过量的添加会导致机械降解。一个需要解决的重要问题是如何在保证足够的力学性能的前提下，获得与人体骨骼相匹配的压电性能。在PMMA骨水泥中加入BT颗粒，即可获得其压电性。在此基础上加入石墨烯，可以在相对较低的BT加入量下获得接近人体骨骼的压电系数。还可以获得高的机械性能。石墨烯通过提高石墨烯(G)/BT(BaTiO3)/PMMA生物压电复合材料的电导率、介电常数和有效极化电压来提高其压电系数。加入0.5%的石墨烯后，上述复合材料的抗压强度由83.5%提高到89.5%，满足了骨植入材料的要求。G/BT/PMMA生物压电复合材料没有细胞毒性，石墨烯还能促进细胞在复合材料表面的黏附和增殖。极化生物-压电复合材料可以改善细胞形态，促进细胞增殖。随着压电系数的增加，晶胞数目增加。该复合材料在口腔、植骨等领域具有潜在的应用前景。
The introduction of BaTiO3(BT) particles into biomaterials, such as polymethyl methacrylate (PMMA) bone cement, is among the effective ways to improve their osteoinductivity. However, excessive addition leads to mechanical degradation. An important problem to solve is the manner by which piezoelectric properties matching human bones can be obtained under the premise of sufficient mechanical properties. The piezoelectric effect is obtained by adding BT particles into PMMA bone cement. The piezoelectric coefficient close to the human bone is obtained at a relatively low BT addition amount by adding graphene on this basis. High mechanical properties can also be obtained. Graphene increases the piezoelectric coefficient by increasing the conductivity, dielectric constant, and effective polarization voltage of graphene (G)/BT(BaTiO3)/PMMA bio-piezoelectric composites. The compression strength of the aforementioned composites increases from 83.5 MPa to 89.5 MPa after the addition of 0.5 vol% graphene, and the requirements of bone implant materials were met. G/BT/PMMA bio-piezoelectric composites have no cytotoxicity, and graphene can also promote cell adhesion and proliferation on the composite's surface. The polarized bio-piezoelectric composites can improve cell morphology and promote cell proliferation. The number of cells increases with increasing piezoelectric coefficient. The composite has potential application prospects in various fields, such as oral cavity and bone implant.
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影响因子：
5.2
作者：
M. L. Hernández;Lizette Morejón Alonso;M. M. Pradas-M.;O. Lozano;Dainelys Guadarrama Bello
通讯作者：
M. L. Hernández;Lizette Morejón Alonso;M. M. Pradas-M.;O. Lozano;Dainelys Guadarrama Bello
影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
3
作者：
Huang, KY;Yan, JJ;Lin, RM
通讯作者：
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