High-speed X-ray-induced luminescence computed tomography.
High-speed X-ray-induced luminescence computed tomography.
复制标题
DOI：
10.1002/jbio.202000066
复制
发表时间：
2020-09
影响因子：
2.8
通讯作者：
Xing L
中科院分区：
文献类型：
--
作者：
Dai X;Cheng K;Zhao W;Xing L
X射线诱导发光计算机断层扫描（XLCT）是一种新兴的分子成像技术。提高空间分辨率和减少全身视场（FOV）中的扫描时间的挑战仍然存在于实际的体内应用中。在这项研究中，我们提出了一种新的XLCT技术，能够获得三维（3D）图像从一个单一的快照。具体地，双平面镜组件被集成到锥束XLCT成像系统中，以同时获得物体的多个光学视图。此外，采用基于压缩感知的算法来提高三维XLCT图像重建的效率。对单次快拍X射线感生发光CT（SS-XLCT）进行了数值模拟和实验验证。结果表明，纳米荧光粉目标的3D分布可以比我们比较中使用的传统锥形束XLCT成像方法更快地可视化，同时保持与传统XLCT成像相当的空间分辨率。SS-XLCT有潜力利用XLCT的能力对小动物进行快速全身体内分子成像。
X-ray-induced luminescence computed tomography (XLCT) is an emerging molecular imaging. Challenges in improving spatial resolution and reducing the scan time in a whole-body field of view (FOV) still remain for practical in vivo applications. In this study, we present a novel XLCT technique capable of obtaining three-dimensional (3D) images from a single snapshot. Specifically, a customed two-planar-mirror component is integrated into a cone beam XLCT imaging system to obtain multiple optical views of an object simultaneously. Furthermore, a compressive sensing based algorithm is adopted to improve the efficiency of 3D XLCT image reconstruction. Numerical simulations and experiments were conducted to validate the single snapshot X-ray-induced luminescence computed tomography (SS-XLCT). The results show that the 3D distribution of the nanophosphor targets can be visualized much faster than conventional cone beam XLCT imaging method that was used in our comparisons while maintaining comparable spatial resolution as in conventional XLCT imaging. SS-XLCT has the potential to harness the power of XLCT for rapid whole-body in vivo molecular imaging of small animals.
登录
查看更多内容
影响因子：
10.8
作者：
Naczynski DJ;Sun C;Türkcan S;Jenkins C;Koh AL;Ikeda D;Pratx G;Xing L
通讯作者：
Xing L
影响因子：
3.6
作者：
Li C;Di K;Bec J;Cherry SR
通讯作者：
Cherry SR
快速 X 射线发光计算机断层扫描成像
影响因子：
4.6
作者：
Liu, Xin;Liao, Qimei;Wang, Hongkai
通讯作者：
Wang, Hongkai
影响因子：
7.6
作者：
Cong AX;Wang G
通讯作者：
Wang G
影响因子：
3.8
作者：
Carpenter, C. M.;Sun, C.;Xing, L.
通讯作者：
Xing, L.