Single-use thermoplastic microfluidic burst valves enabling on-chip reagent storage.

Single-use thermoplastic microfluidic burst valves enabling on-chip reagent storage.
复制标题

一次性热塑性微流体突发阀可实现片固剂的储存。

DOI:
10.1007/s10404-014-1494-8
复制
发表时间:
2015-05-01
影响因子:
2.8
通讯作者:
DeVoe, Don L.
DeVoe, Don L.
中科院分区:
工程技术3区
文献类型:
--
作者:
Rahmanian, Omid D.;DeVoe, Don L.

文献摘要

参考文献

相似文献

提出了一种用于在热塑性微流体装置中制造单次使用的常闭爆破阀的简单且可靠的方法,该方法使用易于集成到用于制造热塑性微流体的已建立的工作流程中的工艺流程。对阀性能的实验研究揭示了阀的几何形状和爆破压力之间的关系。该技术在采用多个阀门的装置中得到了证明,这些阀门被设计成在不同的入口压力下致动,这些入口压力可以使用集成螺杆泵产生。证明了在限定的试剂室内密封的荧光素盐的芯片上存储和重构。通过利用环烯烃共聚物的低气体和水渗透性,坚固的爆破阀允许在芯片上密封储存试剂,使得该技术非常适合开发用于护理点的集成和一次性测定。
A simple and reliable method for fabricating single-use normally closed burst valves in thermoplastic microfluidic devices is presented, using a process flow that is readily integrated into established workflows for the fabrication of thermoplastic microfluidics. An experimental study of valve performance reveals the relationships between valve geometry and burst pressure. The technology is demonstrated in a device employing multiple valves engineered to actuate at different inlet pressures that can be generated using integrated screw pumps. On-chip storage and reconstitution of fluorescein salt sealed within defined reagent chambers are demonstrated. By taking advantage of the low gas and water permeability of cyclic olefin copolymer, the robust burst valves allow on-chip hermetic storage of reagents, making the technology well suited for the development of integrated and disposable assays for use at the point of care.
DOI: 10.1039/c2lc41057e
发表时间: 2013-03-21
期刊: Lab on a chip
影响因子: 6.1
作者:
Rahmanian O;DeVoe DL
通讯作者: DeVoe DL
DOI: 10.1039/c3lc50404b
发表时间: 2013-01-01
期刊: LAB ON A CHIP
影响因子: 6.1
作者:
van Oordt, Thomas;Barb, Yannick;von Stetten, Felix
通讯作者: von Stetten, Felix
DOI: 10.1039/c004980h
发表时间: 2010-01-01
期刊: LAB ON A CHIP
影响因子: 6.1
作者:
Garcia-Cordero, Jose L.;Kurzbuch, Dirk;Ricco, Antonio J.
通讯作者: Ricco, Antonio J.
DOI: 10.1021/la302704t
发表时间: 2012-09-04
期刊: Langmuir : the ACS journal of surfaces and colloids
影响因子: --
作者:
Rahmanian O;Chen CF;DeVoe DL
通讯作者: DeVoe DL
DOI: 10.1039/b803293a
发表时间: 2008-01-01
期刊: LAB ON A CHIP
影响因子: 6.1
作者:
Chen, Guofang;Svec, Frantisek;Knapp, Daniel R.
通讯作者: Knapp, Daniel R.