Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice.
Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice.
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DOI：
10.1007/s00018-022-04379-y
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发表时间：
2022-06-28
影响因子：
8
通讯作者：
Hall, Lindsay J.
中科院分区：
文献类型：
--
作者：
Lopez-Tello, Jorge;Schofield, Zoe;Kiu, Raymond;Dalby, Matthew J.;van Sinderen, Douwe;Le Gall, Gwenaelle;Sferruzzi-Perri, Amanda N.;Hall, Lindsay J.
肠道菌群在调节宿主代谢中起着核心作用。虽然在确定微生物群如何影响出生后及以后的宿主功能方面取得了实质性进展，但对母体肠道微生物群的关键成员如何影响胎儿-胎盘生长知之甚少。值得注意的是，在孕妇中，双歧杆菌是一种关键的有益菌群属，其水平在怀孕期间观察到增加。在这里，我们使用无菌和无特定病原体的小鼠，证明了短双歧杆菌UCC2003调节母体适应性、胎盘结构和营养转运能力，对胎儿代谢和生长有影响。母体和胎盘代谢组受到母体肠道微生物群（即醋酸酯、甲酸酯和肉碱）的影响。胎盘的组织学分析证实，双歧杆菌通过改变Igf2P0、Dlk1、Mapk1和Mapk14的表达来改变胎盘结构。此外，短梭菌UCC2003通过Slc2a1和Fatp1-4转运体起作用，显示出与胎儿肝脏转录组变化相关的胎儿血糖和胎儿生长恢复。我们的工作强调了母体肠道菌群对胎儿-胎盘发育的重要性，并为未来孕期益生菌使用的研究奠定了基础。在线版本包含补充资料，下载地址：10.1007/s00018-022-04379-y。
The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known about how key members of the maternal gut microbiota can influence feto-placental growth. Notably, in pregnant women, Bifidobacterium represents a key beneficial microbiota genus, with levels observed to increase across pregnancy. Here, using germ-free and specific-pathogen-free mice, we demonstrate that the bacterium Bifidobacterium breve UCC2003 modulates maternal body adaptations, placental structure and nutrient transporter capacity, with implications for fetal metabolism and growth. Maternal and placental metabolome were affected by maternal gut microbiota (i.e. acetate, formate and carnitine). Histological analysis of the placenta confirmed that Bifidobacterium modifies placental structure via changes in Igf2P0, Dlk1, Mapk1 and Mapk14 expression. Additionally, B. breve UCC2003, acting through Slc2a1 and Fatp1-4 transporters, was shown to restore fetal glycaemia and fetal growth in association with changes in the fetal hepatic transcriptome. Our work emphasizes the importance of the maternal gut microbiota on feto-placental development and sets a foundation for future research towards the use of probiotics during pregnancy. The online version contains supplementary material available at 10.1007/s00018-022-04379-y.
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影响因子：
3.7
作者：
Godfrey KM;Haugen G;Kiserud T;Inskip HM;Cooper C;Harvey NC;Crozier SR;Robinson SM;Davies L;Southampton Women's Survey Study Group;Hanson MA
通讯作者：
Hanson MA
影响因子：
4.6
作者：
Aoki R;Kamikado K;Suda W;Takii H;Mikami Y;Suganuma N;Hattori M;Koga Y
通讯作者：
Koga Y
影响因子：
64.8
作者：
Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
通讯作者：
Ohno, Hiroshi
影响因子：
4.5
作者：
Frost JM;Moore GE
通讯作者：
Moore GE
影响因子：
5
作者：
Fan, Zhigang;Han, Yang;Cai, Hui
通讯作者：
Cai, Hui