Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.

Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.
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DOI:
10.3390/v13050732
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发表时间:
2021-04-22
期刊:
Viruses
影响因子:
--
通讯作者:
Janowski AB
Janowski AB
中科院分区:
其他
文献类型:
--
作者:
Janowski AB

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Astroviruses are single stranded, positive-sense RNA viruses that have been historically associated with diseases of the gastrointestinal tract of vertebrates, including humans. However, there is now a multitude of evidence demonstrating the capacity of these viruses to cause extraintestinal diseases. The most striking causal relationship is neurological diseases in humans, cattle, pigs, and other mammals, caused by astrovirus infection. Astroviruses have also been associated with disseminated infections, localized disease of the liver or kidneys, and there is increasing evidence suggesting a potential tropism to the respiratory tract. This review will discuss the current understanding of the tissue tropisms for astroviruses and their emerging capacity to cause disease in multiple organ systems.
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