Somatic muscle specification during embryonic and post-embryonic development in the nematode C. elegans.
Somatic muscle specification during embryonic and post-embryonic development in the nematode C. elegans.
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DOI：
10.1002/wdev.15
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发表时间：
2012-03
影响因子：
--
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Krause, Michael;Liu, Jun
肌发生已被证明是一个强大的范例，了解细胞命运的规范和分化，在许多模式生物。秀丽隐杆线虫体细胞体壁肌（BWM）发育的研究使我们能够用单细胞分辨率来定义整个发育过程中肌发生所需的转录调节因子的不同层次。尽管所有95个BWM细胞在分化后看起来是均匀的，但在胚胎和胚胎后存在几种不同的调控级联。这些反过来又被整合到多个外在细胞信号传导事件中。这些不同途径在关键节点上的会聚，即核心肌肉模块的激活，使单个细胞参与肌生成。比较C.秀丽线虫和其他模型系统提供了对收缩细胞类型进化的见解，证明了整个动物王国肌肉调节方案的保守性。
Myogenesis has proved to be a powerful paradigm for understanding cell fate specification and differentiation in many model organisms. Studies of somatic bodywall muscle (BWM) development in Caenorhabditis elegans allow us to define, with single cell resolution, the distinct hierarchies of transcriptional regulators needed for myogenesis throughout development. Although all 95 BWM cells appear uniform after differentiation, there are several different regulatory cascades employed embryonically and post-embryonically. These, in turn, are integrated into multiple extrinsic cell signaling events. The convergence of these different pathways on the key nodal point, that is the activation of the core muscle module, commits individual cells to myogenesis. Comparisons of myogenesis between C. elegans and other model systems provide insights into the evolution of contractile cell types, demonstrating the conservation of regulatory schemes for muscles throughout the animal kingdom.
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