Mesocosm experiments reveal the impact of mosquito control measures on malaria vector life history and population dynamics.

Mesocosm experiments reveal the impact of mosquito control measures on malaria vector life history and population dynamics.
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DOI:
10.1038/s41598-018-31805-8
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发表时间:
2018-09-17
期刊:
影响因子:
4.6
通讯作者:
Ferguson HM
Ferguson HM
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Ng'habi K;Viana M;Matthiopoulos J;Lyimo I;Killeen G;Ferguson HM

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控制措施对蚊子病媒适合度和人口统计的影响通常通过生物测定或现场间接变量来估计。虽然这两种方法都具有指示性,但都不足以量化蚊子种群对综合干预措施的潜在复杂反应。在这里,大规模复制的围隔被用来测量疟疾媒介阿拉伯按蚊的人口水平的反应,长效杀虫蚊帐(LLINs)时,单独使用,或结合杀虫屋檐百叶窗(EL),或治疗牛与endectocide伊维菌素(IM)。状态空间模型(SSM)适合这些实验数据,揭示了LLIN的引入减少了91%的成年蚊子的生存,但允许人口的持久性。ELs没有提供额外的好处,但IM减少了59%的蚊子繁殖力,几乎消除了所有人口时,结合长效驱虫蚊帐。这突出了IM的综合病媒控制的价值,以及与SSM相结合的围隔种群实验,以确定消除病媒种群的最佳组合。
The impact of control measures on mosquito vector fitness and demography is usually estimated from bioassays or indirect variables in the field. Whilst indicative, neither approach is sufficient to quantify the potentially complex response of mosquito populations to combined interventions. Here, large replicated mesocosms were used to measure the population-level response of the malaria vector Anopheles arabiensis to long-lasting insecticidal nets (LLINs) when used in isolation, or combined with insecticidal eave louvers (EL), or treatment of cattle with the endectocide Ivermectin (IM). State-space models (SSM) were fit to these experimental data, revealing that LLIN introduction reduced adult mosquito survival by 91% but allowed population persistence. ELs provided no additional benefit, but IM reduced mosquito fecundity by 59% and nearly eliminated all populations when combined with LLINs. This highlights the value of IM for integrated vector control, and mesocosm population experiments combined with SSM for identifying optimal combinations for vector population elimination.
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