Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: an fMRI study.
Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: an fMRI study.
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DOI：
10.1016/j.neuroimage.2014.05.054
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发表时间：
2014-10-15
期刊：
影响因子：
5.7
通讯作者：
Geliebter A
中科院分区：
文献类型：
--
作者：
Atalayer D;Pantazatos SP;Gibson CD;McOuatt H;Puma L;Astbury NM;Geliebter A
Sexually-dimorphic behavioral and biological aspects of human eating have been described. Using psychophysiological interactions (PPI) analysis, we investigated sex-based differences in functional connectivity with a key emotion-processing region (amygdala, AMG) and a key reward-processing area (ventral striatum, VS) in response to high vs. low energy-dense (ED) food images using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in obese persons in fasted and fed states. When fed, in response to high vs. low-ED food cues, obese men (vs. women) had greater functional connectivity with AMG in right subgenual anterior cingulate, whereas obese women had greater functional connectivity with AMG in left angular gyrus and right primary motor areas. In addition, when fed, AMG functional connectivity with pre/post-central gyrus was more associated with BMI in women (vs. men). When fasted, obese men (vs. women) had greater functional connectivity with AMG in bilateral supplementary frontal and primary motor areas, left precuneus, and right cuneus, whereas obese women had greater functional connectivity with AMG in left inferior frontal gyrus, right thalamus, and dorsomedial prefrontal cortex. When fed, greater functional connectivity with VS was observed in men in bilateral supplementary and primary motor areas, left postcentral gyrus, and left precuneus. These sex-based differences in functional connectivity in response to visual food cues may help partly explain differential eating behavior, pathology prevalence, and outcomes in men and women.
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影响因子：
4.7
作者：
Bates, CJ;Prentice, A;Finch, S
通讯作者：
Finch, S
影响因子：
2.5
作者：
AGGLETON, JP;MISHKIN, M
通讯作者：
MISHKIN, M
影响因子：
5.5
作者：
Davis, Caroline;Levitan, Robert D.;Kennedy, James L.
通讯作者：
Kennedy, James L.
DOI：
10.1523/jneurosci.3323-10.2010
发表时间：
2010-10-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fletcher PC;Napolitano A;Skeggs A;Miller SR;Delafont B;Cambridge VC;de Wit S;Nathan PJ;Brooke A;O'Rahilly S;Farooqi IS;Bullmore ET
通讯作者：
Bullmore ET
DOI：
10.1111/j.1749-6632.1990.tb48913.x
发表时间：
1990-12-31
影响因子：
5.2
作者：
DIAMOND, A
通讯作者：
DIAMOND, A