Inflammaging as a prodrome to Alzheimer's disease.
Inflammaging as a prodrome to Alzheimer's disease.
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DOI：
10.1186/1742-2094-5-51
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发表时间：
2008-11-11
影响因子：
9.3
通讯作者：
Tan J
中科院分区：
文献类型：
--
作者：
Giunta B;Fernandez F;Nikolic WV;Obregon D;Rrapo E;Town T;Tan J
最近，Franceshci及其同事创造了“炎症”一词来描述一个被广泛接受的范式，即衰老伴随着某些促炎反应的低级别慢性上调。炎症与传统的急性炎症的五个主要特征有很大的不同，它的特点是适应性免疫和t -辅助性2反应的相对下降，并与单核吞噬细胞谱系的先天免疫增加有关。虽然在许多老年人中，炎症的过度活跃的先天免疫特征可能仍然是亚临床的，但一部分个体（假设具有“高反应炎症基因型”）可能从“正常”或“亚临床”炎症状态转变为一种或多种与年龄相关的疾病。我们和其他人发现IFN-γ和其他促炎细胞因子与阿尔茨海默病（AD）的病理标志特征a β肽的加工和产生相互作用，表明炎症可能是AD的“前驱症状”。虽然先天免疫反应的增强与促炎蛋白的过量产生与健康衰老和AD相关，但研究表明，那些“衰老良好”的人表现出抗炎机制和生物标志物，可能会抵消炎症的不良免疫反应。因此，对抗炎症的特征可以预防或治疗AD的症状。在这篇综述中，我们全面描述了衰老的免疫系统。此外，我们解释了三种新的治疗方法，(1)人类脐带血细胞（HUCBC），(2)类黄酮和(3)Aβ疫苗接种如何在各种小鼠模型中对抗炎症和ad样病理的力量。
Recently, the term "inflammaging" was coined by Franceshci and colleagues to characterize a widely accepted paradigm that ageing is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses. Inflammaging differs significantly from the traditional five cardinal features of acute inflammation in that it is characterized by a relative decline in adaptive immunity and T-helper 2 responses and is associated with increased innate immunity by cells of the mononuclear phagocyte lineage. While the over-active innate immunity characteristic of inflammaging may remain subclinical in many elderly individuals, a portion of individuals (postulated to have a "high responder inflammatory genotype") may shift from a state of "normal" or "subclinical" inflammaging to one or more of a number of age-associated diseases. We and others have found that IFN-γ and other pro-inflammatory cytokines interact with processing and production of Aβ peptide, the pathological hallmark feature of Alzheimer's disease (AD), suggesting that inflammaging may be a "prodrome" to AD. Although conditions of enhanced innate immune response with overproduction of pro-inflammatory proteins are associated with both healthy aging and AD, it is suggested that those who age "well" demonstrate anti-inflammaging mechanisms and biomarkers that likely counteract the adverse immune response of inflammaging. Thus, opposing the features of inflammaging may prevent or treat the symptoms of AD. In this review, we fully characterize the aging immune system. In addition, we explain how three novel treatments, (1) human umbilical cord blood cells (HUCBC), (2) flavanoids, and (3) Aβ vaccination oppose the forces of inflammaging and AD-like pathology in various mouse models.
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影响因子：
2.5
作者：
Butterfield, DA;Reed, T;Sultana, R
通讯作者：
Sultana, R
影响因子：
5.5
作者：
Bernstein, ED;Gardner, EM;Murasko, DM
通讯作者：
Murasko, DM
影响因子：
9.9
作者：
BREITNER, JCS;GAU, BA;ANTHONY, JC
通讯作者：
ANTHONY, JC
影响因子：
4.4
作者：
Brehin, Anne-Claire;Mouries, Juliette;Couderc, Therese
通讯作者：
Couderc, Therese
DOI：
10.3109/10715768709065294
发表时间：
1987-01-01
期刊：
Free radical research communications
影响因子：
--
作者：
Bors, W;Saran, M
通讯作者：
Saran, M