Multisensory control of multimodal behavior: do the legs know what the tongue is doing?
Multisensory control of multimodal behavior: do the legs know what the tongue is doing?
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DOI：
10.1371/journal.pone.0080465
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Mehta MR
中科院分区：
文献类型：
--
作者：
Cushman JD;Aharoni DB;Willers B;Ravassard P;Kees A;Vuong C;Popeney B;Arisaka K;Mehta MR
对适应行为的理解需要精确控制多感官刺激的呈现，并同时测量多种行为模式。因此，我们开发了一种虚拟现实设备，它允许同时测量奖赏检查和导航行为，以及精确控制视觉、听觉和奖赏刺激的呈现。奖赏检查是联想学习范式中常用的衡量标准。大鼠执行类似于Morris迷宫的虚拟空间导航任务，在该迷宫中，只有远端的视觉或听觉线索提供空间信息。空间导航和奖励检查地图显示了经验依赖的学习，并记录了远端视觉线索。然而，它们表现出一种分离，即远端听觉线索不支持空间导航，但支持空间定位的奖励检查。这些发现表明，大鼠可以在虚拟空间中导航，只有远端的视觉提示，而没有显著的前庭或其他感官输入。此外，它们揭示了两种奖励驱动行为之间的同时分离。
Understanding of adaptive behavior requires the precisely controlled presentation of multisensory stimuli combined with simultaneous measurement of multiple behavioral modalities. Hence, we developed a virtual reality apparatus that allows for simultaneous measurement of reward checking, a commonly used measure in associative learning paradigms, and navigational behavior, along with precisely controlled presentation of visual, auditory and reward stimuli. Rats performed a virtual spatial navigation task analogous to the Morris maze where only distal visual or auditory cues provided spatial information. Spatial navigation and reward checking maps showed experience-dependent learning and were in register for distal visual cues. However, they showed a dissociation, whereby distal auditory cues failed to support spatial navigation but did support spatially localized reward checking. These findings indicate that rats can navigate in virtual space with only distal visual cues, without significant vestibular or other sensory inputs. Furthermore, they reveal the simultaneous dissociation between two reward-driven behaviors.
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影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
3.4
作者：
Hollup, SA;Molden, S;Moser, EI
通讯作者：
Moser, EI
影响因子：
25
作者：
Dombeck, Daniel A.;Harvey, Christopher D.;Tian, Lin;Looger, Loren L.;Tank, David W.
通讯作者：
Tank, David W.
影响因子：
2.5
作者：
HEFFNER, RS;HEFFNER, HE
通讯作者：
HEFFNER, HE
DOI：
10.1073/pnas.94.16.8918
发表时间：
1997-08-05
影响因子：
11.1
作者：
Mehta, MR;Barnes, CA;McNaughton, BL
通讯作者：
McNaughton, BL