Biomarkers for Tobacco Exposures, Toxicology, Regulation, and Cessation.
Biomarkers for Tobacco Exposures, Toxicology, Regulation, and Cessation.
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DOI：
10.1093/ntr/nty004
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发表时间：
2018-03-06
期刊：
影响因子：
--
通讯作者：
Bergen AW
中科院分区：
文献类型：
--
作者：
Bergen AW
本月的《尼古丁与烟草研究》为读者提供了十几篇原创研究论文，评估了急性和慢性烟草暴露对各种行为、发育和代谢反应的影响，以及两篇有关戒烟的编辑精选文章，回顾了“组学”研究，并鼓励未来戒烟基因组研究中的合作。原始研究文章包括动物模型、人类实验室和基于人群的研究，广泛涉及尼古丁或烟草产品暴露的急性或慢性影响。一项动物模型研究表明，麻醉诱导后立即施用尼古丁后，炎症反应途径减少，多巴胺能神经营养途径激活，术后认知功能障碍减少。 1 两项模型研究重点关注水烟烟雾对胚胎发育 2 以及成人学习和记忆的影响。 3 第一项研究在烟草烟雾发育毒理学文献中添加了有机体、组织和基因水平的鸟类模型证据，以及水烟烟雾影响的新证据，而第二项研究则在行为和分子水平上提供了产前暴露对学习和记忆影响的证据。对海马脑源性神经营养因子观察到的影响的对比（术后认知研究观察到急性减少衰减，1）和水烟暴露研究（观察到慢性减少）3，增加了我们对烟草烟雾毒性的理解。
This month’s issue of Nicotine & Tobacco Research provides the reader with a dozen original research papers evaluating the effects of acute and chronic tobacco exposures on a wide variety of behavioral, developmental and metabolic responses, and two linked editor’s choice articles on smoking cessation that review “omic” studies and encourage collaborative efforts in future genomic studies of smoking cessation. The original research articles include animal model, human laboratory, and population-based studies ranging widely over the acute or chronic effects of nicotine or tobacco product exposures.One animal model study demonstrated reduction of the inflammatory response pathway, activation of the dopaminergic neurotropic pathway and reduced postoperative cognitive dysfunction following nicotine administration immediately after anesthesia induction. 1 Two model studies focused on the effects of waterpipe smoke on embryonic development, 2 and adult learning and memory. 3 The first study adds avian model evidence at the organismal, tissue and genic levels to the tobacco smoke developmental toxicology literature and novel evidence for the effects of waterpipe smoke, while the second provides evidence of the effects of prenatal exposure on learning and memory at the behavioral and molecular level. The contrast in effects observed on hippocampal brain derived neurotrophic factor, where the postoperative cognition study observed acute reduction attenuation, 1 and the waterpipe exposure study where chronic reduction was observed, 3 adds to our understanding of the toxicity of tobacco smoke.
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DOI：
10.1093/ntr/ntx093
发表时间：
2018-03-06
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
Teichert A;Brossard P;Felber Medlin L;Sandalic L;Franzon M;Wynne C;Laugesen M;Lüdicke F
通讯作者：
Lüdicke F
影响因子：
4.7
作者：
Saccone, Nancy L.;Emery, Leslie S.;Kaplan, Robert C.
通讯作者：
Kaplan, Robert C.
影响因子：
4.7
作者：
Moon, Katherine A.;Rule, Ana M.;Navas-Acien, Ana
通讯作者：
Navas-Acien, Ana
影响因子：
6.7
作者：
通讯作者：
--
影响因子：
4.7
作者：
Ashour, Anas A.;Haik, Mahmoud Y.;Al Moustafa, Ala-Eddin
通讯作者：
Al Moustafa, Ala-Eddin