Multivariate pattern analysis of the human medial temporal lobe revealed representationally categorical cortex and representationally agnostic hippocampus.
Multivariate pattern analysis of the human medial temporal lobe revealed representationally categorical cortex and representationally agnostic hippocampus.
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人类内侧颞叶的多变量模式分析揭示了代表性分类皮层和代表性不可知海马体。
DOI：
10.1002/hipo.22321
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发表时间：
2014-11
期刊：
影响因子：
3.5
通讯作者：
Stark, Craig E. L.
中科院分区：
文献类型：
--
作者：
Huffman, Derek J.;Stark, Craig E. L.
现代内侧颞叶（MTL）的理论表明，有功能的MTL皮质和海马之间的差异。高分辨率功能磁共振成像和多变量模式分析被用来研究是否MTL亚区可以分类类别的图像，与海马的假设，将代表性较低的分类比MTL皮层。结果显示，显着的分类准确性的面孔与对象和面孔与场景中的MTL皮层区域海马旁皮层和嗅周皮层的类别歧视在海马几乎没有证据。MTL皮质区表现出显着更大的分类准确性比海马。海马显示出显着的分类准确性的图像相比，非记忆基线任务，这表明它响应的图像。包括压后皮质和压后皮质后的后扣带回皮质（RSC/PCC）的感兴趣的区域中的分类准确性，表现出与海马旁皮质相似的结果模式，支持这些区域在功能上相关的假设。结果表明，海马旁皮层，嗅周皮层，RSC/PCC是代表性的分类和海马是更代表性的不可知，这是与海马的作用在模式分离的假设是一致的。
Contemporary theories of the medial temporal lobe (MTL) suggest that there are functional differences between the MTL cortex and the hippocampus. High-resolution functional magnetic resonance imaging and multivariate pattern analysis were utilized to study whether MTL subregions could classify categories of images, with the hypothesis that the hippocampus would be less representationally categorical than the MTL cortex. Results revealed significant classification accuracy for faces versus objects and faces versus scenes in MTL cortical regions—parahippocampal cortex and perirhinal cortex—with little evidence for category discrimination in the hippocampus. MTL cortical regions showed significantly greater classification accuracy than the hippocampus. The hippocampus showed significant classification accuracy for images compared to a non-mnemonic baseline task, suggesting that it responded to the images. Classification accuracy in a region of interest encompassing retrosplenial cortex and the posterior cingulate cortex posterior to retrosplenial cortex (RSC/PCC), showed a similar pattern of results to parahippocampal cortex, supporting the hypothesis that these regions are functionally related. The results suggest that parahippocampal cortex, perirhinal cortex, and RSC/PCC are representationally categorical and the hippocampus is more representationally agnostic, which is concordant with the hypothesis of the role of the hippocampus in pattern separation.
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影响因子：
2.6
作者：
Chadwick MJ;Bonnici HM;Maguire EA
通讯作者：
Maguire EA
影响因子：
3.5
作者：
Duff, Melissa C.;Warren, David E.;Gupta, Rupa;Vidal, Juan Pablo Benabe;Tranel, Daniel;Cohen, Neal J.
通讯作者：
Cohen, Neal J.
DOI：
10.1016/j.cub.2010.01.053
发表时间：
2010-03-23
期刊：
Current biology : CB
影响因子：
--
作者：
Chadwick MJ;Hassabis D;Weiskopf N;Maguire EA
通讯作者：
Maguire EA
影响因子：
16.2
作者：
Hargreaves, Eric L.;Mattfeld, Aaron T.;Suzuki, Wendy A.
通讯作者：
Suzuki, Wendy A.
影响因子：
4.8
作者：
Avants B;Duda JT;Kim J;Zhang H;Pluta J;Gee JC;Whyte J
通讯作者：
Whyte J