Dissociable contributions of prefrontal cortex and the hippocampus to short-term memory: evidence for a 3-state model of memory.
Dissociable contributions of prefrontal cortex and the hippocampus to short-term memory: evidence for a 3-state model of memory.
复制标题
DOI：
10.1016/j.neuroimage.2010.09.002
复制
发表时间：
2011-01-15
期刊：
影响因子：
5.7
通讯作者：
Jonides J
中科院分区：
文献类型：
--
作者：
Nee DE;Jonides J
关于短期记忆（STM）的结构，行为研究得出了相互矛盾的结果。尽管人们已经达成共识，在 STM 中，关注焦点 (FA) 内的单个块具有特权地位，但尚不清楚是否存在进一步的区别。一种建议是，在 FA 之外，记忆都是一种从 STM 到长期记忆 (LTM) 的连续进展。另一方面，当 STM 加载超过 4±1 个项目时，性能急剧下降表明 STM 和 LTM 之间存在区别。我们使用功能磁共振成像（fMRI）来对这些理论进行裁决。神经三重分离为记忆的三态模型提供了证据。重要的是，前额皮质被选择性地增强以从 LTM 的激活部分进行检索，而海马体则与假定的 4±1 容量限制内的项目检索相关。我们假设海马体的联想特性有助于将 STM 中主动维护的信息相互关联，这不仅促进了强大的 STM，而且为后续的 LTM 奠定了基础。相比之下，没有主动记住的信息需要由前额叶皮层介导的自上而下的检索过程。这些数据提供了有关 STM 架构及其与 LTM 关系的重要见解。
Behavioral research has yielded conflicting results regarding the architecture of short-term memory (STM). Whereas a consensus has emerged that within STM a single chunk within the focus of attention (FA) has a privileged status, it is unclear whether further distinctions exist. One proposal is that outside of FA, memory is all of one sort with a continuous progression from STM to long-term memory (LTM). On the other hand, sharp performance drop-offs when STM is loaded with more than 4±1 items suggest distinctions between STM and LTM. We use functional magnetic resonance imaging (fMRI) to adjudicate between these theories. A neural triple dissociation provided evidence for a 3-state model of memory. Critically, prefrontal cortex was selectively enhanced to retrieval from activated portions of LTM whereas the hippocampus was associated with retrieval of items within putative 4±1 capacity limits. We hypothesize that the associative properties of the hippocampus serve to inter-relate information actively maintained in STM which not only promotes strong STM, but also lays the foundations for subsequent LTM. By contrast, information not actively maintained in mind requires top-down retrieval processes mediated by the prefrontal cortex. These data provide key insights into the architecture of STM and its relationship to LTM.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
3.2
作者：
Jonides, J;Marshuetz, C;Hartley, A
通讯作者：
Hartley, A
影响因子：
3.2
作者：
Feredoes, Eva;Postle, Bradley R.
通讯作者：
Postle, Bradley R.
影响因子：
3.3
作者：
Jonides, J;Nee, DE
通讯作者：
Nee, DE