Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region.

Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region.
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DOI:
10.1016/j.cbpa.2022.102131
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发表时间:
2022-06
影响因子:
7.8
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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荧光成像是非侵入性研究细胞和透明生物体生物过程不可或缺的方法。扩展到电磁波谱的短波红外(SWIR,1000-2000 nm)区域,使得哺乳动物成像具有前所未有的光学成像深度和分辨率。在这篇综述中,我们总结了成像技术、染料支架修饰以及将这些染料掺入小鼠短波红外成像探针中的最新进展。最后,我们对短波红外检测在化学生物学领域的未来进行了展望。
Fluorescence imaging is an indispensable method for studying biological processes non-invasively in cells and transparent organisms. Extension into the shortwave infrared (SWIR, 1000–2000 nm) region of the electromagnetic spectrum has allowed for imaging in mammals with unprecedented depth and resolution for optical imaging. In this review, we summarize recent advances in imaging technologies, dye scaffold modifications, and incorporation of these dyes into probes for SWIR imaging in mice. Finally, we offer an outlook on the future of SWIR detection in the field of chemical biology.
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