Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals.
Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals.
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中国两所医院皮肤软组织感染患者金黄色葡萄球菌分子流行病学调查
DOI：
10.4103/0366-6999.190673
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发表时间：
2016-10-05
影响因子：
6.1
通讯作者：
Han LZ
中科院分区：
文献类型：
--
作者：
Gu FF;Chen Y;Dong DP;Song Z;Guo XK;Ni YX;Han LZ
背景资料：金黄色葡萄球菌是皮肤和软组织感染（SSTI）的主要原因之一，但有关S。金黄色葡萄球菌的SSTI患者在中国江苏省。本研究的目的是探讨沙门氏菌的分子流行病学。金黄色葡萄球菌在江苏省两家医院SSTI患者中的分布。方法：选择江苏省两家医院的62例SSTI患者，其中62例SSTI患者的外周血淋巴细胞（PBMC）和外周血淋巴细胞（PBMC）均为阳性。从2014年2月至2015年1月收集金黄色葡萄球菌分离株。S.对金黄色葡萄球菌分离株进行了抗菌药物敏感性试验、毒素基因检测以及序列型、葡萄球菌蛋白A基因型、辅助基因调节子（agr）组和葡萄球菌盒染色体mec型的分子分型。结果：16株（25.8%）耐甲氧西林沙门氏菌;检测到金黄色葡萄球菌（MRSA）分离株，未发现对万古霉素、替考拉宁、磺胺甲恶唑-甲氧苄啶和利奈唑胺耐药的分离株。在SSTI患者中未检测到lukS/F-PV阳性菌株。分子生物学分析表明，ST 398（10/62，16.1%），2 MRSA和8甲氧西林敏感的S。金黄色葡萄球菌（Aaureus）为优势克隆，其次为ST 5（8/62，12.9%）和ST 7（8/62，12.9%）。结论：家畜ST 398是猪链球菌感染者中最常见的克隆。金黄色葡萄球菌SSTI在中国江苏省。因此，对家畜ST 398重要克隆在人类感染中的监测和进一步研究是必要的。
Background: Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections (SSTIs), but limited data were available regarding the characterization of S. aureus from SSTIs patients in Jiangsu Province in China. We aimed to investigate the molecular epidemiology of S. aureus among SSTIs patients in two hospitals of Jiangsu Province. Methods: Sixty-two patients with SSTIs from two Chinese hospitals in Jiangsu Province were enrolled in this study, and 62 S. aureus isolates were collected from February 2014 to January 2015. S. aureus isolates were characterized by antimicrobial susceptibility testing, toxin gene detection, and molecular typing with sequence type, Staphylococcus protein A gene type, accessory gene regulator (agr) group, and Staphylococcal cassette chromosome mec type. Results: Sixteen (25.8%) methicillin-resistant S. aureus (MRSA) isolates were detected, and there was no isolate found resistant to vancomycin, teicoplanin, sulfamethoxazole-trimethoprim, and linezolid. The sei was the toxin gene most frequently found, and no lukS/F-PV-positive isolates were detected among the SSTIs’ patients. Molecular analysis revealed that ST398 (10/62, 16.1%; 2 MRSA and 8 methicillin-susceptible S. aureus) to be the dominant clone, followed by ST5 (8/62, 12.9%) and ST7 (8/62, 12.9%). Conclusions: The livestock ST398 was the most common clone among patients with S. aureus SSTIs in Jiangsu Province, China. Surveillance and further studies on the important livestock ST398 clone in human infections are necessarily requested.
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影响因子：
3.7
作者：
Chen X;Wang WK;Han LZ;Liu Y;Zhang H;Tang J;Liu QZ;Huangfu YC;Ni YX
通讯作者：
Ni YX
上海市七家养老院居民金黄色葡萄球菌患病率及分子流行病学分析
影响因子：
3.7
作者：
Zhang J;Gu FF;Zhao SY;Xiao SZ;Wang YC;Guo XK;Ni YX;Han LZ
通讯作者：
Han LZ
影响因子：
3.3
作者：
Khanna, T.;Friendship, R.;Weese, J. S.
通讯作者：
Weese, J. S.
影响因子：
2
作者：
Gu, Fei-Fei;Han, Li-Zhong;Ni, Yu-Xing
通讯作者：
Ni, Yu-Xing
影响因子：
2.4
作者：
Borgundvaag, Bjug;Wil Ng;Katz, Kevin
通讯作者：
Katz, Kevin