Birth of clones of the world's first cloned dog.
Birth of clones of the world's first cloned dog.
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DOI：
10.1038/s41598-017-15328-2
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发表时间：
2017-11-10
影响因子：
4.6
通讯作者：
Lee BC
中科院分区：
文献类型：
--
作者：
Kim MJ;Oh HJ;Kim GA;Setyawan EMN;Choi YB;Lee SH;Petersen-Jones SM;Ko CJ;Lee BC
动物克隆作为一种生产基因相同的动物或优良动物用于研究或工业用途的方法已经得到了普及。然而，克隆动物是否会加速衰老这一长期存在的问题尚未得到解答。为了回答这个问题，我们比较了世界上第一只克隆狗Snuppy和它的体细胞捐赠者——一只雄性阿富汗猎犬Tai的寿命和健康状况。简单地说，Snuppy和Tai都很健康，直到他们分别在10岁和12岁时患上癌症。捐赠者和克隆狗的寿命都接近阿富汗猎犬的平均寿命，据报道为11.9岁。在这里，我们报告了使用来自Snuppy的脂肪来源的间充质干细胞作为供体细胞的4个克隆的创建。对这些克隆动物终生进行临床和分子随访，将为我们提供一个独特的机会，研究克隆动物与它们的细胞供体相比的健康和寿命。
Animal cloning has gained popularity as a method to produce genetically identical animals or superior animals for research or industrial uses. However, the long-standing question of whether a cloned animal undergoes an accelerated aging process is yet to be answered. As a step towards answering this question, we compared longevity and health of Snuppy, the world’s first cloned dog, and its somatic cell donor, Tai, a male Afghan hound. Briefly, both Snuppy and Tai were generally healthy until both developed cancer to which they succumbed at the ages of 10 and 12 years, respectively. The longevity of both the donor and the cloned dog was close to the median lifespan of Afghan hounds which is reported to be 11.9 years. Here, we report creation of 4 clones using adipose-derived mesenchymal stem cells from Snuppy as donor cells. Clinical and molecular follow-up of these reclones over their lives will provide us with a unique opportunity to study the health and longevity of cloned animals compared with their cell donors.
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影响因子：
64.8
作者：
Wakayama, T;Perry, ACF;Yanagimachi, R
通讯作者：
Yanagimachi, R
影响因子：
1.9
作者：
Kim, Geon A.;Oh, Hyun Ju;Lee, Byeong Chun
通讯作者：
Lee, Byeong Chun
影响因子：
2.8
作者：
Kim, Min Jung;Oh, Hyun Ju;Lee, Byeong Chun
通讯作者：
Lee, Byeong Chun
影响因子：
16.6
作者：
Sinclair KD;Corr SA;Gutierrez CG;Fisher PA;Lee JH;Rathbone AJ;Choi I;Campbell KH;Gardner DS
通讯作者：
Gardner DS
影响因子：
2.8
作者：
Oh, Hyun Ju;Park, Jung Eun;Lee, Byeong Chun
通讯作者：
Lee, Byeong Chun