Neonatal seizures: advances in mechanisms and management.
Neonatal seizures: advances in mechanisms and management.
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DOI：
10.1016/j.clp.2013.10.004
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发表时间：
2014-03
影响因子：
2.1
通讯作者：
Glass HC
中科院分区：
文献类型：
--
作者：
Glass HC
Seizures occur in approximately 1–5 per 1,000 live births, and are among the most common neurologic conditions managed by a neonatal neurocritical care service. There are several, age-specific factors that are particular to the developing brain, which influence excitability and seizure generation, response to medications, and impact of seizures on brain structure and function. Neonatal seizures are often associated with serious underlying brain injury such as hypoxia-ischemia, stroke or hemorrhage. Conventional, prolonged, continuous video-electroencephalogram (cEEG) is the gold standard for detecting seizures, whereas amplitude-integrated EEG (aEEG) is a convenient and useful bedside tool. Evaluation of neonatal seizures involves a thorough search for the etiology of the seizures, and includes detailed clinical history, routine chemistries, neuroimaging (and preferably magnetic resonance imaging, MRI), and specialized testing such as screening for inborn errors of metabolism if no structural cause is identified and seizures persist after correction of transient metabolic deficits. Expert opinion supports rapid medical treatment to abolish electrographic seizures, however the relative risk versus benefit for aggressive medical treatment of neonatal seizures is not known. While there is increasing evidence to support a harmful effect of seizures on the developing brain, there is also evidence that commonly used medications are potentially neurotoxic in animal models. Newer agents appear less harmful, but data are lacking regarding optimal dosing and efficacy.
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影响因子：
3.7
作者：
Cleary RT;Sun H;Huynh T;Manning SM;Li Y;Rotenberg A;Talos DM;Kahle KT;Jackson M;Rakhade SN;Berry G;Jensen FE
通讯作者：
Jensen FE
影响因子：
5.1
作者：
Glass, Hannah C.;Glidden, David;Jeremy, Rita J.;Barkovich, A. James;Ferriero, Donna M.;Miller, Steven P.
通讯作者：
Miller, Steven P.
影响因子：
5.1
作者：
Glass, Hannah C.;Pham, Trinh N.;Wu, Yvonne W.
通讯作者：
Wu, Yvonne W.
影响因子：
9.9
作者：
Boylan, GB;Rennie, JM;Binnie, CD
通讯作者：
Binnie, CD
DOI：
10.1016/b978-0-444-52891-9.00047-6
发表时间：
2013-01-01
期刊：
PEDIATRIC NEUROLOGY, PT I
影响因子：
--
作者：
Dulac, Olivier;Milh, Mathieu;Holmes, Gregory L.
通讯作者：
Holmes, Gregory L.