Microglia subtypes in acute, subacute, and chronic multiple sclerosis.
Microglia subtypes in acute, subacute, and chronic multiple sclerosis.
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DOI：
10.1093/jnen/nlad046
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发表时间：
2023-07-20
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
这项研究旨在研究多发性硬化症(MS)早期和晚期的小胶质细胞形态。对25例档案石蜡包埋组织标本进行免疫组织化学检测。Pío del Río Hortega报道，急性局灶性中枢神经系统损害中的吞噬细胞是从小胶质细胞发展而来的，而浸润性单核细胞没有早期的贡献。在这项研究中，我们无法确定德尔·里奥·霍特加为支持他的理论而引用的变化。相反，MS中的髓鞘吞噬细胞似乎主要来源于浸润性单核细胞。4例斑块边缘可见由MHC-II类抗原阳性的“壁状小胶质细胞”组成的壁，分隔脱髓鞘和交界性有髓组织。2个斑块的壁小胶质细胞伴有AQP4阳性纤维形成的星形胶质细胞。在慢性但非早期疾病的MS病例中，可见小胶质细胞与浸润性单核细胞相互作用，形成几种类型的小胶质细胞结节。此外，MHC II阳性“激活”的小胶质细胞在邻近完整组织中异常突出，几乎没有证据表明正在进行的髓鞘丢失。结论：MS中的髓鞘吞噬细胞完全来源于MRP14阳性的单核细胞，而不是残留的小胶质细胞，Río Hortega的小胶质细胞在MS中起抗炎作用，而不是目前文献所认为的破坏性作用。
The study was designed to examine microglia morphology in early and late forms of multiple sclerosis (MS). Archival paraffin embedded tissue samples from 25 cases were examined immunohistochemically. Pío del Río Hortega reported that phagocytes in acute focal destructive CNS lesions develop from microglia with no early contribution from infiltrating monocytes. In this study, we were unable to identify the changes cited by del Río Hortega in support of his theory. Instead, myelin phagocytes in MS appear to originate chiefly from infiltrating monocytes. In 4 cases, walls composed of MHC class II antigen-positive “wall microglia” were observed at plaque margins separating demyelinated and bordering myelinated tissue. Wall microglia in 2 plaques were accompanied by AQP4-positive fiber-forming astrocytes. In chronic but not early disease MS cases, microglia were seen to interact with infiltrating monocytes to form microglial nodules of several types. Also, MHC II-positive “activated” microglia in bordering intact tissue were exceptionally prominent where there was little evidence of ongoing myelin loss. It is concluded that myelin phagocytes in MS derive entirely from infiltrating MRP14-positive monocytes and not from resident microglia and that Río Hortega’s microglia play an anti-inflammatory role in MS and not the destructive role favored by the current literature.
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影响因子：
3.4
作者：
Pachner AR
通讯作者：
Pachner AR
影响因子：
5.9
作者：
通讯作者：
--
影响因子：
5.8
作者：
Parratt, John D. E.;Prineas, John W.
通讯作者：
Prineas, John W.
DOI：
10.1097/nen.0000000000000149
发表时间：
2015-01-01
影响因子：
3.2
作者：
Peferoen, Laura A. N.;Vogel, Daphne Y. S.;Amor, Sandra
通讯作者：
Amor, Sandra
影响因子：
3.3
作者：
AKIYAMA, H;IKEDA, K;MCGEER, PL
通讯作者：
MCGEER, PL