Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish.
Fasting increases investment in soma upon refeeding at the cost of gamete quality in zebrafish.
复制标题
DOI：
10.1098/rspb.2022.1556
复制
发表时间：
2023-04-12
影响因子：
4.7
通讯作者：
Maklakov, Alexei A.
中科院分区：
文献类型：
--
作者：
Ivimey-Cook, Edward R.;Murray, David S.;de Coriolis, Jean-Charles;Edden, Nathan;Immler, Simone;Maklakov, Alexei A.
禁食可以延长无脊椎动物的寿命，改善脊椎动物健康的生物标志物，并且越来越多地被认为是改善人类健康的有希望的途径。然而，人们对禁食动物在重新进食时如何利用资源以及这些决定如何影响体细胞生长与修复、繁殖和配子质量之间假定的权衡知之甚少。这种禁食引起的权衡是基于强大的理论基础，并且最近在无脊椎动物中被发现，但缺乏脊椎动物的数据。在这里，我们报告说，禁食的雌性斑马鱼在重新喂食后会增加对体细胞的投资，但这是以卵子质量为代价的。具体来说，鳍再生的增加伴随着受精后 24 小时后代存活率的降低。重新喂食的雄性表现出精子速度降低，受精后 24 小时后代存活率受损。这些发现强调，在评估延长寿命治疗对女性和男性的进化和生物医学影响时，有必要考虑对生殖的影响，并呼吁仔细评估间歇性禁食对受精的影响。
Fasting increases lifespan in invertebrates, improves biomarkers of health in vertebrates and is increasingly proposed as a promising route to improve human health. Nevertheless, little is known about how fasted animals use resources upon refeeding, and how such decisions affect putative trade-offs between somatic growth and repair, reproduction and gamete quality. Such fasting-induced trade-offs are based on strong theoretical foundations and have been recently discovered in invertebrates, but the data on vertebrates are lacking. Here, we report that fasted female zebrafish, Danio rerio, increase investment in soma upon refeeding, but it comes at a cost of egg quality. Specifically, an increase in fin regrowth was accompanied by a reduction in 24 h post-fertilization offspring survival. Refed males showed a reduction in sperm velocity and impaired 24 h post-fertilization offspring survival. These findings underscore the necessity of considering the impact on reproduction when assessing evolutionary and biomedical implications of lifespan-extending treatments in females and males and call for careful evaluation of the effects of intermittent fasting on fertilization.
登录
查看更多内容
影响因子：
5.2
作者：
Lee WS;Monaghan P;Metcalfe NB
通讯作者：
Metcalfe NB
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L
DOI：
10.1098/rspb.2017.1721
发表时间：
2017-11-15
影响因子：
4.7
作者：
Berger, David;Stangberg, Josefine;Arnqvist, Goran
通讯作者：
Arnqvist, Goran
影响因子：
3.3
作者：
Gillespie, Stephanie R.;Tudor, M. Scarlett;Miller, Christine W.
通讯作者：
Miller, Christine W.
影响因子：
2.7
作者：
Lardies, MA;Carter, MJ;Bozinovic, F
通讯作者：
Bozinovic, F