Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats.
Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats.
复制标题
DOI：
10.1016/j.physbeh.2011.08.036
复制
发表时间：
2012-01-18
影响因子：
2.9
通讯作者：
Bhatnagar, Seema
中科院分区：
文献类型：
--
作者：
Hong, Suzie;Flashner, Bess;Chiu, Melissa;Hoeve, Elizabeth Ver;Luz, Sandra;Bhatnagar, Seema
啮齿类动物的社会互动是奖励和激励，社会孤立是令人厌恶的。越来越多的证据表明，青春期社会环境的破坏对社会交往、焦虑样行为和压力反应有长期影响。在以前的工作中，我们表明，青春期隔离产生增加的反应，急性和反复的压力，在雌性大鼠，而较低的皮质酮反应急性压力和减少焦虑相关的行为，注意到在孤立的男性。这些结果表明，在青春期的社会压力的影响，性别特异性的影响。然而，很少有人知道社会隔离是否会影响与情感相关的行为，以及它在雄性和雌性大鼠中的作用是否不同。本研究调查了30-50天的青春期社会隔离对雄性和雌性Sprague道利大鼠在青春期结束时和成年时的强迫游泳试验中的行为以及成年时的蔗糖偏好试验中的行为的影响。在青春期隔离的成年雌性大鼠在强迫游泳测试的第一天和第二天表现出增加的攀爬，并且与在青春期分组饲养的成年雌性大鼠相比，表现出对蔗糖的偏好增加。对雄性大鼠无影响。结果表明，青春期的社会隔离在成年雌性大鼠中产生稳定和活跃的行为表型。
Social interactions in rodents are rewarding and motivating and social isolation is aversive. Accumulating evidence suggests that disruption of the social environment in adolescence has long-term effects on social interactions, on anxiety-like behavior and on stress reactivity. In previous work we showed that adolescent isolation produced increased reactivity to acute and to repeated stress in female rats, whereas lower corticosterone responses to acute stress and decreased anxiety-related behavior were noted in isolated males. These results indicate a sex specific impact on the effects of social stress in adolescence. However, little is known about whether social isolation impacts behaviors related to affect and whether it does so differently in male and female rats. The present study investigated the impact of adolescent social isolation from day 30-50 of age in male and female Sprague Dawley rats on behavior in the forced swim test at the end of adolescence and in adulthood and on behavior in the sucrose preference test in adulthood. Adult female rats that were isolated in adolescence exhibited increased climbing on the first and second day of the forced swim test and showed an increased preference for sucrose compared to adult females that were group-housed in adolescence. There were no effects in male rats. The results indicate that social isolation in adolescence produces a stable and active behavioral phenotype in adult female rats.
登录
查看更多内容
影响因子：
4.6
作者：
Hankin, Benjamin L.;Mermelstein, Robin;Roesch, Linda
通讯作者：
Roesch, Linda
影响因子：
3.4
作者：
MUSCAT, R;PAPP, M;WILLNER, P
通讯作者：
WILLNER, P
影响因子：
2.2
作者：
EINON, DF;HUMPHREYS, AP;NAYLOR, V
通讯作者：
NAYLOR, V
影响因子：
2.3
作者：
Leussis, Melanie P.;Andersen, Susan L.
通讯作者：
Andersen, Susan L.
影响因子：
2.3
作者：
Detke, MJ;Johnson, J;Lucki, I
通讯作者：
Lucki, I