LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance.
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DOI：
10.1016/j.neuron.2017.07.028
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发表时间：
2017-08-16
期刊：
影响因子：
16.2
通讯作者：
Castillo PE
中科院分区：
文献类型：
--
作者：
Hashimotodani Y;Nasrallah K;Jensen KR;Chávez AE;Carrera D;Castillo PE
海马齿状回中的兴奋性肺门苔藓细胞(MCs)接受齿状颗粒细胞(GCs)的输入，并投射回局部、对侧和沿海马体纵轴方向的GCs，从而建立一个联合正反馈回路，连接不同功能的海马区。MCS还与GABA能中间神经元突触，介导对GC的前馈抑制。令人惊讶的是，尽管这些回路与记忆形成(例如，模式分离)和颞叶癫痫有关，但对它们的突触连接的活动依赖性可塑性知之甚少。在此，我们报道了MC-GC突触经历了突触前、NMDA受体非依赖性的长时程增强(LTP)，这需要突触后脑源性神经营养因子(BDNF)/TrkB和突触前环磷酸腺苷(CAMP)/PKA信号。这种LTP是输入特异性的，并选择性地在MC-GC突触表达，但不在双突触抑制环表达。通过增加兴奋/抑制平衡，MC-GC LTP增强了联合MC-GC循环回路的GC输出，并可能有助于齿状依赖形式的学习和癫痫。
Excitatory hilar mossy cells (MCs) in the dentate gyrus receive inputs from dentate granule cells (GCs) and project back to GCs locally, contralaterally, and along the longitudinal axis of the hippocampus, thereby establishing an associative positive-feedback loop and connecting functionally diverse hippocampal areas. MCs also synapse with GABAergic interneurons that mediate feed-forward inhibition onto GCs. Surprisingly, although these circuits have been implicated in both memory formation (e.g., pattern separation) and temporal lobe epilepsy, little is known about activity-dependent plasticity of their synaptic connections. Here, we report that MC-GC synapses undergo a presynaptic, NMDA-receptor-independent form of long-term potentiation (LTP) that requires postsynaptic brain-derived neurotrophic factor (BDNF)/TrkB and presynaptic cyclic AMP (cAMP)/PKA signaling. This LTP is input specific and selectively expressed at MC-GC synapses, but not at the disynaptic inhibitory loop. By increasing the excitation/inhibition balance, MC-GC LTP enhances GC output at the associative MC-GC recurrent circuit and may contribute to dentate-dependent forms of learning and epilepsy.
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影响因子：
16.2
作者：
Danielson NB;Turi GF;Ladow M;Chavlis S;Petrantonakis PC;Poirazi P;Losonczy A
通讯作者：
Losonczy A
影响因子：
16.2
作者：
Fanselow, Michael S.;Dong, Hong-Wei
通讯作者：
Dong, Hong-Wei
影响因子：
2.5
作者：
DEADWYLER, SA;WEST, JR;LYNCH, GS
通讯作者：
LYNCH, GS
影响因子：
16.2
作者：
GoodSmith D;Chen X;Wang C;Kim SH;Song H;Burgalossi A;Christian KM;Knierim JJ
通讯作者：
Knierim JJ
影响因子：
4.7
作者：
Anwyl, R.
通讯作者：
Anwyl, R.