An unprecedented cluster of Australian bat lyssavirus in Pteropus conspicillatus indicates pre-flight flying fox pups are at risk of mass infection.
An unprecedented cluster of Australian bat lyssavirus in Pteropus conspicillatus indicates pre-flight flying fox pups are at risk of mass infection.
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DOI：
10.1111/zph.12703
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发表时间：
2020-06
影响因子：
2.4
通讯作者：
Smith C
中科院分区：
文献类型：
--
作者：
Barrett J;Höger A;Agnihotri K;Oakey J;Skerratt LF;Field HE;Meers J;Smith C
2017年11月，来自远北昆士兰州不同地点的两组P.显着幼仔出现了与澳大利亚蝙蝠狂犬病毒（ABLV）感染一致的神经系统体征。这些幼仔（n = 11）在11天内死亡，并提交给政府实验室进行检测，确认ABLV感染。在接下来的几周里，在昆士兰州的狐蝠中也发现了额外的ABLV病例。在此期间，来自ABLV感染的飞狐的脑组织以及存档的脑组织被选择用于下一代测序。系统发育分析表明，这两组幼仔都是从单一来源感染的。它们很可能是在晚上在托儿所的时候被暴露的，因为它们的母兽在觅食。这项研究确定了处于大规模ABLV感染潜在高风险的托儿所年龄幼仔。
In November 2017, two groups of P. conspicillatus pups from separate locations in Far North Queensland presented with neurological signs consistent with Australian bat lyssavirus (ABLV) infection. These pups (n = 11) died over an 11-day period and were submitted to a government laboratory for testing where ABLV infection was confirmed. Over the next several weeks, additional ABLV cases in flying foxes in Queensland were also detected. Brain tissue from ABLV-infected flying foxes during this period, as well as archived brain tissue, was selected for next-generation sequencing. Phylogenetic analysis suggests that the two groups of pups were each infected from single sources. They were likely exposed while in crèche at night as their dams foraged. This study identifies crèche-age pups at a potentially heightened risk for mass ABLV infection.
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