Biomimetic scaffold design for functional and integrative tendon repair.
Biomimetic scaffold design for functional and integrative tendon repair.
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DOI：
10.1016/j.jse.2011.11.016
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发表时间：
2012-02
影响因子：
3
通讯作者：
Lu, Helen H.
中科院分区：
文献类型：
--
作者：
Zhang, Xinzhi;Bogdanowicz, Danielle;Erisken, Cevat;Lee, Nancy M.;Lu, Helen H.
肩袖撕裂是美国最常见的肩关节损伤。这种退行性疾病的衰弱效应加上与现有移植物选择相关的高失败率，强调了对替代移植解决方案的临床需求。理想肌腱移植物的两个关键设计标准要求移植物不仅表现出生理相关的机械性能，而且能够通过促进天然肌腱-骨界面的再生来促进功能性移植物整合。围绕这些设计目标，本文将重点介绍目前的功能性和综合性肌腱修复方法。特别是，仿生设计原理的应用，通过使用肌腱组织工程的纳米复合材料为基础的支架将被讨论。这篇综述将开始与纳米纤维为基础的方法来功能性肌腱修复，其次是一节突出肌腱-骨界面再生的令人兴奋的研究，重点是实施战略仿生学在肌腱支架设计和随之而来的形成分级多组织系统的综合软组织修复。本次审查将以总结和未来方向部分结束。
Rotator cuff tears represent the most common shoulder injuries in the United States. The debilitating effect of this degenerative condition coupled with the high incidence of failure associated with existing graft choices underscore the clinical need for alternative grafting solutions. The two critical design criteria for the ideal tendon graft would require the graft to not only exhibit physiologically relevant mechanical properties but also be able to facilitate functional graft integration by promoting the regeneration of the native tendon-to-bone interface. Centered on these design goals, this review will highlight current approaches to functional and integrative tendon repair. In particular, the application of biomimetic design principles through the use of nanofiber- and nanocomposite-based scaffolds for tendon tissue engineering will be discussed. This review will begin with nanofiber-based approaches to functional tendon repair, followed by a section highlighting the exciting research on tendon-to-bone interface regeneration, with an emphasis on implementation of strategic biomimicry in nanofiber scaffold design and the concomitant formation of graded multi-tissue systems for integrative soft tissue repair. This review will conclude with a summary and future directions section.
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DOI：
10.1002/jbm.820291107
发表时间：
1995-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
DUNN, MG;LIESCH, JB;ZAWADSKY, JP
通讯作者：
ZAWADSKY, JP
影响因子：
14
作者：
Bashur, Chris A.;Dahlgren, Linda A.;Goldstein, Aaron S.
通讯作者：
Goldstein, Aaron S.
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
影响因子：
--
作者：
Garvin, J;Qi, B;Banes, AJ
通讯作者：
Banes, AJ
DOI：
10.1016/j.bioeng.2006.05.017
发表时间：
2007-02-01
期刊：
BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Garreta, E.;Gasset, D.;Borros, S.
通讯作者：
Borros, S.