Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.
Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.
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DOI：
10.1186/s12968-021-00813-5
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发表时间：
2021-10-25
期刊：
影响因子：
--
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Thompson EW;Kamesh Iyer S;Solomon MP;Li Z;Zhang Q;Piechnik S;Werys K;Swago S;Moon BF;Rodgers ZB;Hall A;Kumar R;Reza N;Kim J;Jamil A;Desjardins B;Litt H;Owens A;Witschey WRT;Han Y
肥厚型心肌病（HCM）的特征是左心室壁厚度增加，心肌细胞肥大和纤维化。已使用晚期钆增强（LGE）、天然T1和细胞外容积（ECV）进行不良心脏风险表征。弛豫时间常数受背景场不均匀性的影响。T1ρ利用自旋锁定脉冲来减少不必要的弛豫效应。本研究的目的是研究HCM患者的T1ρ与T1、ECV和LGE的比较。 HCM患者被招募作为肥厚性心肌病研究中新的预后标志物的一部分，并与健康对照组进行比较。除心脏功能成像外，受试者还在1.5T短轴位置进行T1和T1ρ心血管磁共振成像。受试者接受钆，并在注射后15-20分钟接受覆盖整个心脏的LGE成像。选择相应的基底和中短轴LGE切片与T1和T1ρ进行比较。采用半高宽阈值法，通过LGE、T1和T1ρ确定每个LGE阳性切片的增强面积百分比。两名临床医生独立审查LGE图像是否存在增强。如果一致，则将图像标记为阳性（LGE + +）或阴性（LGE −−）;否则，将图像标记为可疑（LGE + −）。 在40例HCM患者和10例对照组中，T1增强面积百分比（斯皮尔曼rho = 0.61，p <1 e-5）和T1ρ增强面积百分比（斯皮尔曼rho = 0.48，p < 0.001e-3）与LGE增强面积百分比相关。T1和T1ρ增强面积百分比也相关（斯皮尔曼rho = 0.28，p = 0.047）。对于T1和T1ρ，HCM患者在每个LGE类别中均表现出与对照组相比显著更长的松弛时间（所有p < 0.001）。HCM患者在每个LGE类别中的ECV也显著高于对照组（所有p < 0.01），LGE −−切片的ECV低于LGE + +（p = 0.01）。通过T1ρ和LGE测量的超增强区域具有中度相关性。与对照组相比，HCM患者的T1、T1ρ和ECV均升高，无论是否存在LGE。这些发现需要进一步的研究来探讨T1ρ成像在HCM患者评估中的预后效用。
Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular wall thickness, cardiomyocyte hypertrophy, and fibrosis. Adverse cardiac risk characterization has been performed using late gadolinium enhancement (LGE), native T1, and extracellular volume (ECV). Relaxation time constants are affected by background field inhomogeneity. T1ρ utilizes a spin-lock pulse to decrease the effect of unwanted relaxation. The objective of this study was to study T1ρ as compared to T1, ECV, and LGE in HCM patients. HCM patients were recruited as part of the Novel Markers of Prognosis in Hypertrophic Cardiomyopathy study, and healthy controls were matched for comparison. In addition to cardiac functional imaging, subjects underwent T1 and T1ρ cardiovascular magnetic resonance imaging at short-axis positions at 1.5T. Subjects received gadolinium and underwent LGE imaging 15–20 min after injection covering the entire heart. Corresponding basal and mid short axis LGE slices were selected for comparison with T1 and T1ρ. Full-width half-maximum thresholding was used to determine the percent enhancement area in each LGE-positive slice by LGE, T1, and T1ρ. Two clinicians independently reviewed LGE images for presence or absence of enhancement. If in agreement, the image was labeled positive (LGE + +) or negative (LGE −−); otherwise, the image was labeled equivocal (LGE + −). In 40 HCM patients and 10 controls, T1 percent enhancement area (Spearman’s rho = 0.61, p < 1e-5) and T1ρ percent enhancement area (Spearman’s rho = 0.48, p < 0.001e-3) correlated with LGE percent enhancement area. T1 and T1ρ percent enhancement areas were also correlated (Spearman’s rho = 0.28, p = 0.047). For both T1 and T1ρ, HCM patients demonstrated significantly longer relaxation times compared to controls in each LGE category (p < 0.001 for all). HCM patients also showed significantly higher ECV compared to controls in each LGE category (p < 0.01 for all), and LGE −− slices had lower ECV than LGE + + (p = 0.01). Hyperenhancement areas as measured by T1ρ and LGE are moderately correlated. T1, T1ρ, and ECV were elevated in HCM patients compared to controls, irrespective of the presence of LGE. These findings warrant additional studies to investigate the prognostic utility of T1ρ imaging in the evaluation of HCM patients.
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影响因子：
3.7
作者：
Berisha S;Han J;Shahid M;Han Y;Witschey WR
通讯作者：
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7.5
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6.4
作者：
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通讯作者：
Witschey, Walter R. T.