Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany.
Evidence for extensive genotypic diversity and recombination of GB virus C (GBV-C) in Germany.
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DOI：
10.1002/jmv.22029
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发表时间：
2011-04
影响因子：
12.7
通讯作者：
Blackard, Jason T.
中科院分区：
文献类型：
--
作者：
Neibecker, Markus;Schwarze-Zander, Carolynne;Rockstroh, Juergen K.;Spengler, Ulrich;Blackard, Jason T.
GB病毒C（GBV-C）的多种基因型-一种非致病性黄病毒-迄今已被确定，尽管它们在世界范围内的分布并不均匀。也有人认为GBV-C基因型可能在调节HIV疾病中发挥作用;然而，在大多数国家，GBV-C的患病率和基因型分布尚未得到充分研究。在德国的408例HIV阳性受试者中，97例（23.8%）检出GBV-C RNA。根据5′非翻译区（5′UTR）的测序结果，GBV-C基因型为1（n = 8; 8.2%）、2（n = 81; 83.5%）和3（n = 2; 2.1%），以及一种以前未报道的独特基因型（n = 6; 6.2%）。在17个E2区测序的样本中，14个样本的5′UTR和E2区基因型结果一致，3个样本的E2区序列存在基因型间重组。这些结果表明，基因型多样性和病毒重组有助于GB病毒C的整体遗传变异。
Multiple genotypes of GB virus C (GBV-C) – a non-pathogenic flavivirus – have been identified to date, although they are not uniformly distributed worldwide. It has also been suggested that GBV-C genotype may play a role in modulating HIV disease; however, the prevalence and genotype distribution of GBV-C has not been adequately studied in most countries. Among 408 HIV positive subjects in Germany, 97 (23.8%) had detectable GBV-C RNA. Based on sequencing of the 5′ untranslated region (5′UTR), the GBV-C genotypes were 1 (n = 8; 8.2%), 2 (n = 81; 83.5%), and 3 (n = 2; 2.1%), as well as a unique genotype not previously reported (n = 6; 6.2%). Among 17 samples also sequenced in the envelope 2 (E2) region, 14 had concordant genotype results when comparing the 5′UTR and E2, while evidence of intergenotypic recombination was observed among E2 sequences from 3 individuals. These results suggest that genotypic diversity and viral recombination contribute to the overall genetic variability of GB virus C.
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