Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative.
Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative.
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DOI：
10.1007/s00256-020-03550-5
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发表时间：
2021-01
影响因子：
2.1
通讯作者：
Link TM
中科院分区：
文献类型：
--
作者：
Kanthawang T;Bodden J;Joseph GB;Lane NE;Nevitt M;McCulloch CE;Link TM
研究[i]使用非对比增强磁共振成像（MRI）探究体重指数（BMI）与膝关节滑膜炎之间的关系，以及[ii]滑膜炎与退行性异常和疼痛之间的关联。
从骨关节炎倡议（Osteoarthritis Initiative）中选取有患骨关节炎风险以及轻度至中度影像学骨关节炎的受试者。将受试者按BMI分为三组，每组87人：正常体重组（BMI为20 - 24.9 kg/m²）、超重组（BMI为25 - 29.9 kg/m²）和肥胖组（BMI≥30 kg/m²），在年龄、性别、种族、凯尔格伦 - 劳伦斯（Kellgren - Lawrence）分级、膝关节手术及损伤史方面进行频数匹配。获取半定量滑膜炎成像生物标志物，包括积液 - 滑膜炎、髌下脂肪垫信号异常的大小和强度以及滑膜增生评分。使用T2弛豫时间测量软骨成分，使用全器官磁共振成像评分（WORMS）测量结构异常。采用西安大略和麦克马斯特大学（Western Ontario and McMasters，WOMAC）骨关节炎指数进行疼痛评估。通过κ值评估阅片者内和阅片者间的可重复性。
超重组和肥胖组所有滑膜炎标志物的患病率和严重程度均较高（p≤0.03）。发现滑膜炎成像生物标志物与平均T2值、WORMS最高评分以及WOMAC疼痛总评分之间呈正相关（p<0.05）。成像生物标志物的阅片者内和阅片者间κ值较高（分别为0.76 - 1.00和0.60 - 0.94）。
超重或肥胖与滑膜炎成像生物标志物更高的患病率和严重程度显著相关。良好的可重复性以及与膝关节结构、软骨成分退变和WOMAC疼痛评分的高度相关性验证了本研究中使用的滑膜炎生物标志物。
To study [i] the relationship between Body Mass Index (BMI) and knee synovial inflammation using non-contrast enhanced MRI and [ii] the association of synovial inflammation versus degenerative abnormalities and pain. Subjects with risk for and mild to moderate radiographic osteoarthritis were selected from the Osteoarthritis Initiative. Subjects were grouped into three BMI categories with 87 subjects per group: normal weight (BMI 20–24.9 kg/m2), overweight (BMI 25–29.9 kg/m2), and obese (BMI ≥ 30 kg/m2), frequency matched for age, sex, race, Kellgren-Lawrence grade, history of knee surgery and injury. Semi-quantitative synovial inflammation imaging biomarkers were obtained including effusion-synovitis, size and intensity of infrapatellar fat pad signal abnormality and synovial proliferation score. Cartilage composition was measured using T2 relaxation time and structural abnormalities using the whole-organ magnetic resonance imaging score (WORMS). The Western Ontario and McMasters (WOMAC) Osteoarthritis Index was used for pain assessment. Intra- and inter-reader reproducibility was assessed by kappa values. Overweight and obese groups had higher prevalence and severity of all synovial inflammatory markers (p≤0.03). Positive associations were found between synovial inflammation imaging biomarkers and average T2 values, WORMS maximum scores and total WOMAC pain scores (p<0.05). Intra-reader and inter-reader kappa values for imaging biomarkers were high (0.76–1.00 and 0.60–0.94 respectively). Being overweight or obese was significantly associated with a greater prevalence and severity of synovial inflammation imaging biomarkers. Substantial reproducibility and high correlation with knee structural, cartilage compositional degeneration, and WOMAC pain scores validate the synovial inflammation biomarkers used in this study.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
2.8
作者：
Chuckpaiwong, Bavornrit;Charles, Hal Cecil;Kraus, Virginia B.;Guilak, Farshid;Nunley, James A.
通讯作者：
Nunley, James A.
影响因子：
27.4
作者：
Han, Weiyu;Aitken, Dawn;Ding, Changhai
通讯作者：
Ding, Changhai
影响因子：
1.9
作者：
LANDIS, JR;KOCH, GG
通讯作者：
KOCH, GG
DOI：
10.1002/jmri.25766
发表时间：
2018-03
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Chanchek N;Gersing AS;Schwaiger BJ;Nevitt MC;Neumann J;Joseph GB;Lane NE;Zarnowski J;Hofmann FC;Heilmeier U;McCulloch CE;Link TM
通讯作者：
Link TM